Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity
Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity
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DOI：
10.1016/j.bbrc.2007.06.070
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发表时间：
2007-08-24
影响因子：
3.1
通讯作者：
Fujii, Shingo
中科院分区：
文献类型：
--
作者：
Baba, Tsukasa;Mori, Seiichi;Fujii, Shingo
卵巢癌是妇科恶性肿瘤妇女死亡的主要原因，晚期肿瘤的预后取决于化疗反应和肿瘤切除的成功。由于RAS通路的异常激活在卵巢癌中很常见，因此研究体外RAS诱导的卵巢表面上皮细胞转化及其伴随的基因组表达变化对于开发新的治疗方式和了解肿瘤发生是必要的。基因芯片分析显示，在RAS诱导下，参与囊胚着床的亲同型粘附分子TROPHONIN （TRO）是下调最多的基因之一。TRO在顺铂敏感的癌细胞系中表达较高，并与卵巢癌预后呈正相关。通过RNA干扰敲低TRO可产生顺铂耐药性，并导致培养的卵巢癌细胞侵袭性增加。这些发现强调了TRO在肿瘤发生中的重要性，并提示TRO可能是顺铂敏感性和侵袭潜力的有用生物标志物。(C) 2007爱思唯尔公司版权所有。
Ovarian cancer is the leading cause of death in women with gynecological malignancies, with prognosis of advanced stage tumors determined by chemotherapeutic response and the success of tumor resection. Since aberrant RAS pathway activation is frequent in ovarian cancer, study of in vitro RAS-induced transformation and accompanying genomic expression changes in ovarian surface epithelial cells is imperative for development of new therapeutic modalities and for understanding tumorigenesis. cDNA microarray analysis revealed TROPHONIN (TRO), a homophilic adhesion molecule involved in blastocyst implantation, was among the genes most downregulated by RAS induction. TRO expression is higher in cisplatin-sensitive cancer cell lines and positively correlates with prognoses in ovarian cancers. TRO knockdown by RNA interference conferred cisplatin resistance and led to increased invasiveness of cultured ovarian cancer cells. These findings underscore the importance of TRO in tumorigenesis, and suggest that TRO may be a useful biomarker for cisplatin sensitivity and invasive potential. (C) 2007 Elsevier Inc. All rights reserved.