Is Growth Hormone Deficiency a Useful Diagnosis?
Is Growth Hormone Deficiency a Useful Diagnosis?
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生长激素缺乏症是有用的诊断吗？
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
P. Smith
中科院分区：
文献类型：
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作者：
C. Brook;P. Hindmarsh;P. Smith
有证据表明，从生长速度差的儿童（分泌很少，以前称为生长激素缺乏）到生长速度正常的儿童（分泌大量），内源性生长激素的分泌是连续的。矮小儿童生长速度和生长激素分泌之间的关系用渐近回归来描述。此外，生长和生长激素之间的关系由生长激素脉冲幅度调制。这种关系的治疗意义是，任何矮小的儿童给予生长激素都会生长得更快，而那些生长最慢、内源性生长激素分泌最少的儿童，在标准剂量的外源性生长激素的作用下，身高速度的增量最大。
Evidence is presented that there is a continuum in endogenous hGH secretion ranging from those children with poor growth velocities who secrete very little, formerly called hGH deficient, to those with normal growth velocities who secrete a much greater amount. The relationship between growth velocity and hGH secretion in short children is described by an asymptotic regression. Further, the relationship between growth and hGH is modulated by hGH pulse amplitude. The therapeutic implications of this relationship are that any short child given hGH will grow more rapidly, and that those children growing most slowly with the least endogenous hGH secretion will have the greatest increment in height velocity for a standard dose of exogenous hGH.