Selective Swelling of Block Copolymer Nanoparticles: Size, Nanostructure, and Composition
Selective Swelling of Block Copolymer Nanoparticles: Size, Nanostructure, and Composition
复制标题
嵌段共聚物纳米颗粒的选择性溶胀：尺寸、纳米结构和组成
DOI：
10.1021/ma500123g
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发表时间：
2014-04-22
期刊：
影响因子：
5.5
通讯作者：
Jin, Zhaoxia
中科院分区：
文献类型：
--
作者：
Fan, Hailong;Jin, Zhaoxia
摘要：介孔聚合物纳米粒子在药物输送、生物工程和催化等领域有着广泛的应用。嵌段共聚物（BCP）的选择性溶胀是制备可控、可开关多孔聚合物纳米结构的一种很有前途的方法.嵌段共聚物纳米结构的选择性溶胀研究表明，溶胀条件、嵌段共聚物的组成、嵌段共聚物的结构和尺寸都与溶胀过程中的结构转变有关。为了更清楚地了解这些因素的影响，我们比较了两种不同尺寸和组成的BCP纳米颗粒，大胶束和洋葱状颗粒的溶胀行为。分别研究了嵌段共聚物的组成、嵌段共聚物纳米颗粒的纳米结构和嵌段共聚物纳米颗粒的尺寸，以了解这些因素如何影响溶胀速度、溶胀过程中的结构转变和最终的溶胀纳米结构。这项研究有助于我们理解如何优雅地控制嵌段共聚物的选择性溶胀所产生的多孔结构。
Supporting InformationABSTRACT: Mesoporous polymer nanoparticles have broad applications indrug delivery, bioengineering, and catalysis. Selective swelling of blockcopolymer (BCP) is one promising strategy to generate controllable andswitchable porous polymer nanostructures. Previous studies of selective swellingof block copolymer nanostructures revealed that the swelling condition, BCPcomposition, their architectures and sizes are involved in structural trans-formation in swelling. To clearly understand the effect of these factors, hereinwe compared the swelling behaviors of two types BCP nanoparticles, largecompound micelles, and onion-like particles, with different sizes andcompositions. The composition of block copolymers, the nanostructure ofblock copolymer nanoparticles, and the size of block copolymer nanoparticlesare investigated separately to understand how these factors intertwine indetermining swelling speed, structural transformation in swelling process, andthe final swollen nanostructures. This study helps us understand how to elegantly control the porous structure generated byselective swelling of block copolymers.