Slow oscillation electrical brain stimulation during waking promotes EEG theta activity and memory encoding
Slow oscillation electrical brain stimulation during waking promotes EEG theta activity and memory encoding
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DOI：
10.1073/pnas.0904438106
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发表时间：
2009-09-08
影响因子：
11.1
通讯作者：
Marshall, Lisa
中科院分区：
文献类型：
--
作者：
Kirov, Roumen;Weiss, Carsten;Marshall, Lisa
先前显示，在以新兴内源性慢振荡活动为特征的睡眠期间应用经颅慢振荡刺激（tSOS；0.75 Hz）可增强广泛的内源性脑电图慢振荡活动。通常在这种睡眠状态下发生的记忆巩固过程也得到了增强。在这里，我们表明，在清醒的大脑中应用相同的 tSOS 也会诱导内源性脑电图慢振荡 (0.4-1.2 Hz) 的增加，尽管是以地形限制的方式。此外，在清醒状态下应用 tSOS 会导致脑电图 theta (4-8 Hz) 活动显着且广泛增加。在清醒期间，学习后应用 tSOS 并不会增强记忆巩固，但在学习过程中应用时可以改善海马依赖性记忆的编码。我们得出的结论是，tSOS 引起的脑电图频率和相关记忆过程很大程度上取决于大脑状态。为了响应清醒期间的 tSOS，大脑通过优先响应 θ 振荡和促进编码来转移刺激。
The application of transcranial slow oscillation stimulation (tSOS; 0.75 Hz) was previously shown to enhance widespread endogenous EEG slow oscillatory activity when applied during a sleep period characterized by emerging endogenous slow oscillatory activity. Processes of memory consolidation typically occurring during this state of sleep were also enhanced. Here, we show that the same tSOS applied in the waking brain also induced an increase in endogenous EEG slow oscillations (0.4-1.2 Hz), although in a topographically restricted fashion. Applied during wakefulness tSOS, additionally, resulted in a marked and widespread increase in EEG theta (4-8 Hz) activity. During wake, tSOS did not enhance consolidation of memories when applied after learning, but improved encoding of hippocampus-dependent memories when applied during learning. We conclude that the EEG frequency and related memory processes induced by tSOS critically depend on brain state. In response to tSOS during wakefulness the brain transposes stimulation by responding preferentially with theta oscillations and facilitated encoding.