Reduced Cerebral Blood Flow in Mild Cognitive Impairment Assessed Using Phase-Contrast MRI
Reduced Cerebral Blood Flow in Mild Cognitive Impairment Assessed Using Phase-Contrast MRI
复制标题
DOI：
10.3233/jad-161222
复制
发表时间：
2017-01-01
影响因子：
4
通讯作者：
Fernandez-Seara, Maria A.
中科院分区：
文献类型：
--
作者：
Garcia de Eulate, Reyes;Goni, Irene;Fernandez-Seara, Maria A.
越来越多的证据表明，血管因素与阿尔茨海默病(AD)有关。在某些情况下，先前的工作表明，慢性脑低灌流可能是导致淀粉样β蛋白积聚的主要致病因素，而其他研究支持这样的假设，即血管功能障碍和淀粉样蛋白病理是独立的，尽管是协同的，但导致认知障碍的机制。血管功能障碍可以通过评估脑血流障碍来评估。MRI的相位对比速度图提供了一种非侵入性的方法来量化流入大脑的血液总量。这一定量指标可作为AD早期血管病变的敏感指标。在这项工作中，使用相位对比MRI来评估主观记忆主诉、遗忘性轻度认知障碍和轻中度AD患者的脑血流动力学，并与对照组进行比较。结果表明，认知功能障碍患者的血流速度和血流速度均下降，并与认知功能障碍的程度相关。AD患者的总脑血流量测量明显减少，但更重要的是，它似乎足够敏感，足以区分健康受试者和轻度认知障碍者。对总脑血流量的定量测量有可能预测AD早期的血管功能障碍和脑血流灌注受损。
There is increasing evidence of a vascular contribution to Alzheimer's disease (AD). In some cases, prior work suggests that chronic brain hypoperfusion could play a prime pathogenic role contributing to the accumulation of amyloid-beta, while other studies favor the hypothesis that vascular dysfunction and amyloid pathology are independent, although synergistic, mechanisms contributing to cognitive impairment. Vascular dysfunction can be evaluated by assessing cerebral blood flow impairment. Phase contrast velocity mapping by MRI offers a non-invasive means of quantifying the total inflow of blood to the brain. This quantitative parameter could be a sensitive indicator of vascular disease at early stages of AD. In this work, phase contrast MRI was used to evaluate cerebral hemodynamics in patients with subjective memory complaints, amnestic mild cognitive impairment, and mild to moderate AD, and compare them with control subjects. Results showed that blood flow and velocity were decreased in the patients with cognitive dysfunction and the decrease correlated with the degree of cognitive impairment as assessed by means of neuropsychological tests. Total cerebral blood flow measurements were clearly reduced in AD patients, but more importantly appeared to be sensitive enough to distinguish between healthy subjects and those with mild cognitive impairment. A quantitative measurement of total brain blood flow could potentially predict vascular dysfunction and compromised brain perfusion in early stages of AD.