High expression of cyclic nucleotide phosphodiesterase 7B mRNA predicts poor prognosis in mantle cell lymphoma
High expression of cyclic nucleotide phosphodiesterase 7B mRNA predicts poor prognosis in mantle cell lymphoma
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环核苷酸磷酸二酯酶 7B mRNA 高表达预示套细胞淋巴瘤预后不良
DOI：
10.1016/j.leukres.2013.02.006
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发表时间：
2013-05-01
影响因子：
2.7
通讯作者：
Li, Jian-Yong
中科院分区：
文献类型：
--
作者：
Fang, Cheng;Dong, Hua-Jie;Li, Jian-Yong
为了确定环核苷酸磷酸二酯酶异构体7 B（PDE 7 B）表达与套细胞淋巴瘤（MCL）进展之间的关系，通过qRT-PCR测量21名未经治疗的骨髓受累的MCL患者和20名健康供体中PDE 7 B mRNA的表达。PDE 7 B在MCL患者中的表达水平明显高于正常对照组（P = 0.001），且PDE 7 B的高表达水平与MCL的不良细胞遗传学特征相关。提示PDE 7 B高表达可能是MCL预后不良的新指标，具有重要的临床意义。(C)2013爱思唯尔有限公司保留所有权利。
In order to determine the relationship between expression of cyclic nucleotide phosphodiesterase isoform 7B (PDE7B) and mantle cell lymphoma (MCL) progression, PDE7B mRNA expression was measured by qRT-PCR in 21 untreated MCL patients with bone marrow involvement and 20 healthy donors. The expression level of PDE7B was markedly higher in MCL patients compared with normal controls (P = 0.001), and the higher level of PDE7B expression was associated with unfavorable cytogenetic characteristics in MCL. It was showed that higher expression of PDE7B might be a novel unfavorable prognostic indicator in MCL, which possess important clinical significance. (C) 2013 Elsevier Ltd. All rights reserved.