Twin study of symptom dimensions in psychoses
Twin study of symptom dimensions in psychoses
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DOI：
10.1192/bjp.179.1.39
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发表时间：
2001-07-01
影响因子：
10.5
通讯作者：
McGuffin, P
中科院分区：
文献类型：
--
作者：
Cardno, AG;Sham, PC;McGuffin, P
精神疾病的症状学可以概括为定量的症状维度。但它们的遗传基础尚不清楚。目的探讨基因是否对症状维度有重要影响。方法从伦敦莫兹利双胞胎登记簿中对224对有精神病的先证双胞胎（同卵106对，异卵118对）进行分析。对精神障碍操作检查表（OPCRIT）评定的终生症状进行因素分析。对研究诊断标准精神病的同卵和异卵对的维度评分进行相关性分析。使用逻辑回归评估维度得分与精神病遗传负荷之间的关系。结果与遗传效应一致的家族聚集模式在无组织维度和消极、躁狂和一般精神病维度的一些测量中被发现。无组织维度得分与精神病的遗传负荷显著相关。结论紊乱维度，可能还有其他症状维度。可能是精神病分子遗传学研究的有用表型。
Background Symptomatology in psychoses can be summarised as quantitative symptom dimensions. but their genetic basis is unknown.Aims To investigate whether genes make an important contribution to symptom dimensions.Method A total of 224 probandwise twin pairs (106 monozygotic, 118 same-gender dizygotic) where probands had psychosis were ascertained from the Maudsley Twin Register in London. Factor analysis was performed on lifetime symptoms rated on the Operational Checklist for Psychotic Disorders (OPCRIT). Correlations of dimension scores within monozygotic and dizygotic pairs concordant for Research Diagnostic Criteria psychoses were performed. Relationships between dimension scores and genetic loading for psychoses were assessed using logistic regression.Results Patterns of familial aggregation consistent with a genetic effect were found for the disorganised dimension and for some measures of the negative, manic and general psychotic dimensions. Disorganised dimension scores were related significantly to genetic loading for psychoses.Conclusions The disorganised dimension, and possibly other symptom dimensions. may be useful phenotypes for molecular genetic studies of psychoses.