In-vivo whole bladder response to anticholinergic and musculotropic agents in spinal cord injured rats.
In-vivo whole bladder response to anticholinergic and musculotropic agents in spinal cord injured rats.
复制标题
脊髓损伤大鼠体内全膀胱对抗胆碱能药物和肌肉生长药物的反应。
DOI：
10.1080/10790268.1997.11719389
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
T. E. Figueroa
中科院分区：
文献类型：
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作者：
P. Shenot;M. Chancellor;D. Rivas;T. Watanabe;H. Kumon;T. E. Figueroa
本研究的目的是比较抗胆碱能药物和促肌药物对假损伤和脊髓损伤(SCI)大鼠尿动力学参数的影响。采用标准的大鼠脊髓撞击伤模型。脊髓损伤后4周在乌拉坦麻醉下进行膀胱测压。在尿动力学和目测监测下，在排尿点测定膀胱容量和排尿压力。分别观察盐酸奥昔布宁(0.01~0.1 mg/kg)、溴化丙氨酸乙酯(0.05~0.5 mg/kg)和盐酸黄酮酯(0.1~1.0 mg/kg)对假手术和脊髓损伤大鼠的影响。假手术组和脊髓损伤组大鼠膀胱容量分别为0.6+/-0.2和7.1+/-1.6ml(P<；0.01)。假手术组最大充盈压为17.5+/-5 mm Hg，脊髓损伤组为25+/-5 mm Hg(p<；0.05)。三种药物均可增加膀胱容量。在假手术组，奥昔布宁、丙氨酸乙酯和黄酮酯的膀胱容量分别为0.88+/-0.3、0.71+/-0.3和0.8+/-0.2ml(p<；0.01)。在脊髓损伤大鼠，这三种药物的膀胱容量分别为9.8+/-1.1、7.9+/-1.3和8.8+/-2.0ml(p<；0.01)。最大灌装压力没有明显变化。我们得出结论，抗胆碱能药物和促肌药物在假手术大鼠和脊髓损伤大鼠中都能引起类似的膀胱容量增加。奥昔布宁对膀胱容量的促进作用强于丙氨酸乙酯或黄酮酸盐。
The purpose of this study was to compare the effect on urodynamic parameters of anticholinergic and musculotropic agents in sham injured and spinal cord injured (SCI) rats. A standard rat SCI model induced by impact trauma was employed. Cystometrograms were performed under urethane anesthesia four weeks after SCI. Bladder capacity and voiding pressure were determined at the point of micturition monitored urodynamically and visually. The effect of oxybutynin chloride (0.01-0.1 mg/kg), propantheline bromide (0.05-0.5 mg/kg) and flavoxate hydrochloride (0.1-1.0 mg/kg) were assessed independently in sham injured and SCI rats (n = 10 in each group). Bladder capacities were 0.6 +/- 0.2 and 7.1 +/- 1.6 ml in sham and SCI rats (p < 0.01), respectively. Maximal filling pressure was 17.5 +/- 5 mmHg in sham and 25 +/- 5 mmHg in SCI rats (p < 0.05). Bladder capacity increased with all three medications. Administration of oxybutynin, propantheline and flavoxate in sham rats resulted in bladder capacities of 0.88 +/- 0.3, 0.71 +/- 0.3 and 0.8 +/- 0.2 ml, respectively (p < 0.01). In SCI rats, these drugs resulted in bladder capacities of 9.8 +/- 1.1, 7.9 +/- 1.3 and 8.8 +/- 2.0 ml, respectively (p < 0.01). No significant change in maximum filling pressure occurred. We conclude that anticholinergic and musculotropic agents caused a similar increase in bladder capacity in both sham and SCI rats. Oxybutynin enhanced bladder capacity more than propantheline or flavoxate.
膀胱平滑肌肥大和退化过程中平滑肌肌球蛋白亚型的表达。
DOI：
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发表时间：
1995
期刊：
Laboratory investigation; a journal of technical methods and pathology.
影响因子：
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作者：
Wang,ZE;Gopalakurup,SK;Levin,RM;Chacko,S
通讯作者：
Chacko,S