Concomitant administration of nitrous oxide and remifentanil reduces oral tissue blood flow without decreasing blood pressure during sevoflurane anesthesia in rabbits
Concomitant administration of nitrous oxide and remifentanil reduces oral tissue blood flow without decreasing blood pressure during sevoflurane anesthesia in rabbits
复制标题
DOI：
10.1007/s00540-014-1944-1
复制
发表时间：
2015-06-01
影响因子：
2.8
通讯作者：
Matsuura, Nobuyuki
中科院分区：
文献类型：
--
作者：
Kasahara, Masataka;Ichinohe, Tatsuya;Matsuura, Nobuyuki
为了确定在七氟醚麻醉期间连续给予一氧化二氮和瑞芬太尼（单独或一起）是否会改变口腔组织中的血流量，在机械通气下用七氟醚麻醉8只气管切开的日本白色雄性家兔。心率（HR）、收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）、颈总动脉血流量（CCBF）、舌粘膜血流量（TMBF）、下颌骨骨髓血流量（BBF）、咬肌血流量（MBF）、上牙槽组织血流量（UBF），在不存在所有测试试剂的情况下和在施用测试试剂后记录下肺泡组织血流量（LBF（50%一氧化二氮、0.4 μ g/kg/min瑞芬太尼及其组合）20分钟。一氧化二氮相对于基线值增加SBP、DBP、MAP、CCBF、BBF、MBF、UBF和LBF，但不影响HR或TMBF。瑞芬太尼降低除DBP外的所有血流动力学变量。笑气和瑞芬太尼联合给药使SBP、DBP、MAP和CCBF恢复至基线水平，但HR和口腔组织血流量仍低于对照值。我们的研究结果表明，在家兔七氟醚麻醉期间，笑气和瑞芬太尼联合给药可减少口腔组织血流量，但不会降低血压。
To determine whether continuous administration of nitrous oxide and remifentanil-either alone or together-alters blood flow in oral tissues during sevoflurane anesthesia.Eight male tracheotomized Japanese white rabbits were anesthetized with sevoflurane under mechanical ventilation. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), common carotid arterial blood flow (CCBF), tongue mucosal blood flow (TMBF), mandibular bone marrow blood flow (BBF), masseter muscle blood flow (MBF), upper alveolar tissue blood flow (UBF), and lower alveolar tissue blood flow (LBF) were recorded in the absence of all test agents and after administration of the test agents (50 % nitrous oxide, 0.4 mu g/kg/min remifentanil, and their combination) for 20 min.Nitrous oxide increased SBP, DBP, MAP, CCBF, BBF, MBF, UBF, and LBF relative to baseline values but did not affect HR or TMBF. Remifentanil decreased all hemodynamic variables except DBP. Combined administration of nitrous oxide and remifentanil recovered SBP, DBP, MAP, and CCBF to baseline levels, but HR and oral tissue blood flow remained lower than control values.Our findings suggest that concomitant administration of nitrous oxide and remifentanil reduces blood flow in oral tissues without decreasing blood pressure during sevoflurane anesthesia in rabbits.