A Vps21 endocytic module regulates autophagy.

A Vps21 endocytic module regulates autophagy.
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Vps21 内吞模块调节自噬

DOI:
10.1091/mbc.e14-04-0917
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发表时间:
2014-10-15
影响因子:
3.3
通讯作者:
Segev N
Segev N
中科院分区:
生物学3区
文献类型:
--
作者:
Chen Y;Zhou F;Zou S;Yu S;Li S;Li D;Song J;Li H;He Z;Hu B;Björn LO;Lipatova Z;Liang Y;Xie Z;Segev N

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Vps21除了参与内吞作用外,还参与自噬。内吞Vps21模块成员的单个缺失,包括一个GEF和四个效应子,会导致自噬缺陷和自噬体簇的积累。因此,内吞Vps21模块调节自噬。
Vps21 plays a role in autophagy in addition to its role in endocytosis. Individual deletions of members of the endocytic Vps21 module, including a GEF and four effectors, result in autophagy defects and accumulation of autophagosomal clusters. Therefore the endocytic Vps21 module regulates autophagy.