Phantom-Based Feasibility Studies on Phase-Contrast Mammography at Indian Synchrotron Facility Indus-2
Phantom-Based Feasibility Studies on Phase-Contrast Mammography at Indian Synchrotron Facility Indus-2
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DOI：
10.4103/jmp.jmp_98_18
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发表时间：
2019-01-01
影响因子：
0.9
通讯作者：
Datta, D.
中科院分区：
文献类型：
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作者：
Sharma, Reena;Sharma, S. D.;Datta, D.
同步辐射（SR）X射线源在医学成像中的应用已经显示出极大的潜力，以提高软组织图像的对比度，如乳房。本研究证明了定量X射线相位衬度成像（XPCI）技术来自乳腺组织等效测试材料中观察到的传播依赖性相变。材料与方法：印度同步加速器设施（Indus-2，Raja Ramanna先进技术中心[RRCAT]）用于进行相位对比乳腺X射线摄影的体模可行性研究。使用不同的体模和样品，包括局部制造的乳腺组织等效体模，使用12和16 keV SR X射线束进行吸收和相位模式成像。测量所有图像的边缘增强指数（EE 1）和边缘增强噪声比（EE/N）。使用在物平面处测量的SR X射线光子通量并通过应用标准辐射剂量学形式主义，计算12和16 keV SR X射线束的空气吸收剂量值。结果与结论：在所有体模和测试样本的情况下观察到，对于在相位模式下拍摄的图像，EEI和EE/N值相对较高。12和16 keV SR能量下，成像平面处的空气吸收剂量分别为75.59 mGy和28.9 mGy。然而，这些剂量值可以通过减少图像采集时间来优化，而不损害临床样本成像时的图像质量。这项工作证明了使用12和16 keV SR X射线束进行XPCI在乳房X光检查中的可行性。
Use of synchrotron radiation (SR) X-ray source in medical imaging has shown great potential for improving soft-tissue image contrast such as the breast. The present study demonstrates quantitative X-ray phase-contrast imaging (XPCI) technique derived from propagation-dependent phase change observed in the breast tissue-equivalent test materials. Materials and Methods: Indian synchrotron facility (lndus-2, Raja Ramanna Centre of Advanced Technology [RRCAT]) was used to carry out phantom feasibility study on phase-contrast mammography. Different phantoms and samples, including locally fabricated breast tissue-equivalent phantoms were used to perform absorption and phase mode imaging using 12 and 16 keV SR X-ray beam. Edge-enhancement index (EEl) and edge enhancement to noise ratio (EE/N) were measured for all the images. Absorbed dose to air values were calculated for 12 and 16 keV SR X-ray beam using the measured SR X-ray photon flux at the object plane and by applying the standard radiation dosimetry formalism. Results and Conclusion: It was observed in case of all the phantoms and test samples that EEI and EE/N values are relatively higher for images taken in the phase mode. The absorbed dose to air at imaging plane was found to be 75.59 mGy and 28.9 mGy for 12 and 16 keV SR energies, respectively. However, these dose values can be optimized by reducing the image acquisition time without compromising the image quality when clinical samples are imaged. This work demonstrates the feasibility of XPCI in mammography using 12 and 16 keV SR X-ray beams.