DECISION-MAKING PERFORMANCE IS RELATED TO LEVELS OF ANXIETY AND DIFFERENTIAL RECRUITMENT OF FRONTOSTRIATAL AREAS IN MALE RATS
DECISION-MAKING PERFORMANCE IS RELATED TO LEVELS OF ANXIETY AND DIFFERENTIAL RECRUITMENT OF FRONTOSTRIATAL AREAS IN MALE RATS
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DOI：
10.1016/j.neuroscience.2011.02.025
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发表时间：
2011-06-16
期刊：
影响因子：
3.3
通讯作者：
van den Bos, R.
中科院分区：
文献类型：
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作者：
De Visser, L.;Baars, A. M.;van den Bos, R.
在人类中，高水平的焦虑与爱荷华州赌博任务（IGT）中的不良表现有关。IGT衡量不确定条件下的决策。在这项研究中，我们调查了大鼠的焦虑和决策之间的关联。在高架十字迷宫（elevated plus maze）中筛选大鼠的焦虑，随后在IGT大鼠类似物（r-IGT）中进行测试。我们在最后一次训练后使用c-fos免疫组织化学探讨了与r-IGT表现相关的额纹区的作用。高水平的焦虑与不良的r-IGT表现：高焦虑大鼠作出更少的选择，为有利的选择，并收集更少的蔗糖颗粒在r-IGT比低焦虑大鼠。对有利选项的选择的赢-留/输-移行为的分析显示，表现良好的低焦虑受试者在试验块中表现出赢-留的增加和输-移的减少，而表现不佳的高焦虑受试者则没有。此外，决策能力和焦虑水平间接地与内侧前额叶皮层的神经活动有关，即前边缘和边缘下皮层，以及纹状体的部分，即核壳和核心。这些数据表明，在人类和大鼠中，类似的额纹状体回路是情感决策的基础。(C)2011由Elsevier Ltd代表IBRO出版。
In humans, high levels of anxiety are associated with poor performance in the Iowa Gambling Task (IGT). The IGT measures decision-making under conditions of uncertainty. In this study, we investigated the association between anxiety and decision-making in rats. Rats were screened for anxiety on the elevated plus maze (EPM) and subsequently tested in a rat analogue of the IGT (r-IGT). We explored the role of frontostriatal areas related to r-IGT performance using c-fos immunohistochemistry following the last training-session. High levels of anxiety were associated with poor r-IGT performance: high anxious rats made fewer choices for the advantageous option and collected fewer sucrose pellets in the r-IGT than low anxious rats. Analysis of win-stay/lose-shift behaviour of choices for the advantageous option revealed that good performing-low anxious subjects showed an increase in win-stays and a decrease in lose-shifts across trial blocks while poor performing-high anxious subjects did not. Furthermore, decision-making performance and, indirectly, anxiety levels were related to neural activity in parts of the medial prefrontal cortex, that is prelimbic and infralimbic cortex, and in parts of the striatum, that is nucleus accumbens shell and core. These data suggest a similar frontostriatal circuitry underlying affective decision-making in humans and rats. (C) 2011 Published by Elsevier Ltd on behalf of IBRO.