Local recurrence following breast conservation therapy in African-American women with invasive breast cancer
Local recurrence following breast conservation therapy in African-American women with invasive breast cancer
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DOI：
10.1016/s0002-9610(99)00258-5
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发表时间：
2000-01-01
影响因子：
3
通讯作者：
Mayo, MS
中科院分区：
文献类型：
--
作者：
Connor, CS;Touijer, AK;Mayo, MS
BACKGROUND: African-American women have a lower survival rate than white women following a diagnosis of invasive breast cancer. Limited information is available regarding the impact of race on results of breast conservation therapy (BCT).METHODS: Local recurrence rates were compared in 71 African-American patients (73 breasts) and 204 white patients (208 breasts) with stage I and II breast cancer treated with BCT.RESULTS: Overall 5-year actuarial recurrence rates were 13% in African-Americans and 4% in whites (P = 0.075), These rates were 9% and 4%, respectively, if patients with local skin/soft tissue recurrences were excluded (P = 0.587). Exclusion of these skin/soft tissue failures eliminated any significant difference seen in recurrence between stage II African-American and white patients (P = 0.163), African-American women had less favorable recurrences, including tumor in more than one quadrant or local skin/soft tissue involvement (P = 0.001),CONCLUSIONS: Overall actuarial recurrence rates were slightly higher, but not significantly different, in African-American and white women following BCT, A much less favorable pattern of local recurrence was seen in the African-American patients (P = 0.001), which may represent the presence of more biologically aggressive tumors in these women. (C) 2000 by Excerpta Medica, Inc.
