Evaluation of cancer risk in patients with periodontal diseases
Evaluation of cancer risk in patients with periodontal diseases
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DOI：
10.3906/sag-1812-8
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发表时间：
2019-01-01
影响因子：
2.3
通讯作者：
Hayran, Mutlu
中科院分区：
文献类型：
--
作者：
Guven, Deniz Can;Dizdar, Omer;Hayran, Mutlu
背景/目的：在本研究中，我们旨在评估牙周病患者的癌症风险。材料和方法：纳入 2007 年至 2012 年间在 Hacettepe 大学诊断为牙周病的患者，并从患者档案中收集牙周病后诊断为任何癌症的数据。使用土耳其国家癌症登记处 2013 年数据计算年龄和性别标准化发病率 (SIR)。结果：总共纳入 5199 名患者。中位随访时间为 7.2 年。与相应年龄和性别组的预期计数相比，患有牙周病的患者患癌症的风险增加了 17%（SIR：1.17；95% CI：1.04-1.3，P = 0.006）。女性癌症风险增加具有统计学意义（SIR：1.24；95% CI：1.05-1.45，P = 0.008），但男性则不然。在患有牙周病的女性中，乳腺癌（SIR：2.19）和头颈癌（SIR：4.71）的风险显着增加。在男性中，前列腺癌（SIR：1.84）、头颈癌（SIR：3.55）和血液癌（SIR：1.76）的风险显着增加。 结论：这项研究表明，牙周病与多种癌症的风险增加有关。除了其他众所周知的健康益处外，还应考虑提供口腔/牙齿健康并将其用作癌症预防措施。
Background/aim: In this study, we aimed to assess the cancer risk among patients with periodontal disease.Materials and methods: Patients diagnosed with periodontal diseases at Hacettepe University between 2007 and 2012 were included and data on the diagnosis of any cancer after periodontal disease were collected from patient files. The age-and sex-standardized incidence rates (SIRs) were calculated using Turkish National Cancer Registry 2013 data.Results: A total of 5199 patients were included. Median follow-up was 7.2 years. Patients with periodontal diseases had 17% increased risk of cancer compared with the expected counts for the corresponding age and sex groups (SIR: 1.17; 95% CI: 1.04-1.3, P = 0.006). The increased cancer risk was statistically significant in women (SIR: 1.24; 95% CI: 1.05-1.45, P = 0.008) but not in men. Among women with periodontal disease, the risks of breast cancer (SIR: 2.19) and head and neck cancer (SIR: 4.71) were significantly increased. Among men, the risks of prostate cancer (SIR: 1.84), head and neck cancer (SIR: 3.55), and hematological cancers (SIR: 1.76) were significantly increased.Conclusion: This study showed that periodontal diseases were associated with increased risk of several cancers. Besides other well-known benefits for health, the provision of oral/dental health should be considered and employed as a cancer prevention measure.