Bidirectional alloreactivity: A proposed microchimerism-based solution to the NIMA paradox.
Bidirectional alloreactivity: A proposed microchimerism-based solution to the NIMA paradox.
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DOI：
10.4161/chim.21668
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发表时间：
2012-04-01
期刊：
影响因子：
--
通讯作者：
Benichou, Gilles
中科院分区：
文献类型：
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作者：
Burlingham, William J;Benichou, Gilles
NIMA悖论是观察到在同种异体肾脏或造血干细胞移植中，兄弟姐妹从再次暴露于非遗传性母体抗原（NIMA）中获益，而再次暴露于母亲自身（理论上理想的“NIMA”供体）的移植并不产生优于父亲捐赠的同种异体移植的临床结果。最近对肾脏和脐带血移植中双向同种异体反应的观察为这一悖论提供了一个可能的解决方案。如果正确的话，提出的解决方案为微嵌合在实体器官和造血移植中的临床应用指明了道路。
The NIMA paradox is the observation that in transplants of allogeneic kidneys or hematopoietic stem cells, siblings benefit from re-exposure to non-inherited maternal antigens (NIMA), whereas re-exposure to a transplant from mother herself, theoretically the ideal "NIMA" donor, does not yield clinical results superior to a father-donated allograft. Recent observations of bidirectional alloreactivity in kidney and cord blood transplantation offer a possible solution to this paradox. If correct, the proposed solution points the way to clinical applications of microchimerism in solid organ and hematopoetic transplants.