Perspectives in the study of thyroid hormone action on brain development and function
Perspectives in the study of thyroid hormone action on brain development and function
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DOI：
10.1089/105072503770867174
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发表时间：
2003-11-01
期刊：
影响因子：
6.6
通讯作者：
Morte, B
中科院分区：
文献类型：
--
作者：
Bernal, J;Guadaño-Ferraz, A;Morte, B
这篇综述的目的是提供一个最新的报告，甲状腺激素作为一个表观遗传因素在脑成熟的作用所涉及的分子和生理过程。我们总结了现有的数据控制脑基因表达的甲状腺激素，基因表达和生理效应之间的相关性，以及甲状腺激素对脑基因表达的作用机制。此外，我们提出了甲状腺激素受体在甲状腺功能减退症的发病机制中的作用。最后，我们回顾了最近的数据表明，甲状腺激素受体对行为的影响。
The purpose of this review is to provide an up-to-date report on the molecular and physiologic processes involved in the role of thyroid hormone as an epigenetic factor in brain maturation. We summarize the available data on the control of brain gene expression by thyroid hormone, the correlation between gene expression and physiologic effects, and the likely mechanisms of action of thyroid hormone on brain gene expression. In addition we propose a role for unliganded thyroid hormone receptors in the pathogenesis of hypothyroidism. Finally, we review recent data indicating that thyroid hormone receptors have an impact on behavior.