The Effects of Low Vitamin D on Coronary Artery Disease
The Effects of Low Vitamin D on Coronary Artery Disease
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DOI：
10.1016/j.hlc.2013.08.012
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发表时间：
2014-04-01
影响因子：
2.6
通讯作者：
Sha, Yuan
中科院分区：
文献类型：
--
作者：
Chen, Wei Ren;Qian, Yong An;Sha, Yuan
目的冠状动脉疾病（Coronary Artery Disease，CAD）是世界范围内发病率和死亡率最高的疾病之一.低维生素D状态已被证明与心血管疾病、高血压和肥胖的风险增加有关。我们计划研究低维生素D状态和CAD的严重程度之间的关联。程序共348例接受冠状动脉造影评估CAD的连续患者被纳入本研究。25-用化学发光法测定羟维生素D [25（OH）D]。使用SYNTAX评分评估CAD严重程度。结果：冠心病患者血清25（OH）D水平为18.2 +/- 10.6 ng/ml。SYNTAX评分为27.8 +/- 8.5。多元线性回归分析（校正年龄、高敏C反应蛋白、SYNTAX评分、甲状旁腺激素、体重指数、血红蛋白和肌酐）显示，血清25（OH）D水平与SYNTAX评分和高敏C反应蛋白（hsCRP）水平呈负相关。Logistic回归分析确定25（OH）D是与高SYNTAX评分相关的独立因素。维生素D水平在25（OH）D类别最低（30 ng/ml）的患者。结论低维生素D水平与冠状动脉狭窄程度相关。
Purpose Coronary Artery Disease (CAD) remains a major cause of morbidity and mortality in the world. Low vitamin D status has been shown to be associated with increased risk of developing cardiovascular disease, hypertension and obesity. We planned to research the association between low vitamin D status and the severity of CAD.Procedures A total of 348 consecutive patients undergoing coronary angiography for evaluation of CAD were included in this study. 25-Hydroxyvitamin D [25(OH)D] was measured by chemiluminescence assay. CAD severity was assessed by using the SYNTAX scores. The data presented are the mean levels/values and standard deviation.Findings The serum 25(OH)D level of CAD patients was 18.2 +/- 10.6 ng/ml. The SYNTAX scores were 27.8 +/- 8.5. In a multivariate linear regression analysis (adjusted for age, high-sensitivity C-reactive protein, SYNTAX score, parathyroid hormone, body mass index, haemoglobin and creatinine), the serum 25(OH)D level showed a negative correlation with SYNTAX score and high-sensitivity C-reactive protein (hsCRP) level. Logistic regression analysis identified 25(OH)D as an independent factor related to high SYNTAX scores. Patients whose vitamin D levels were in the lowest 25(OH)D category (30 ng/ml).Conclusion Low vitamin D is associated with the severity of coronary artery stenosis.