Menopause, cognitive ageing and dementia: practice implications.
Menopause, cognitive ageing and dementia: practice implications.
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DOI：
10.1258/mi.2009.009003
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发表时间：
2009-03-01
期刊：
影响因子：
--
通讯作者：
Henderson, Victor W
中科院分区：
文献类型：
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作者：
Henderson, Victor W
情景记忆受到认知衰老的影响，超出正常衰老预期的记忆障碍可能是阿尔茨海默病的早期指标。尽管记忆问题在中年很常见，但令人欣慰的是，自然的更年期过渡并没有伴随着客观的记忆丧失。人们对手术绝经后的记忆知之甚少。在绝经后晚期开始的含雌激素的激素治疗会增加患痴呆症的风险，并且不会改善记忆力。目前尚不清楚绝经过渡期间或绝经后早期激素的使用是否会影响阿尔茨海默病的风险。观察性研究表明存在与所谓的关键窗口假说一致的保护性关联，但这些发现可能存在偏差。提出了临床实践意义。
Episodic memory is affected by cognitive ageing, and memory impairment beyond that expected on the basis of usual ageing may be an early indicator of Alzheimer's disease. Although memory complaints are common in midlife, it is reassuring that the natural menopausal transition is unaccompanied by objective memory loss. Less is known about memory after surgical menopause. Estrogen-containing hormone therapy initiated during the late postmenopause increases dementia risk and does not improve memory. It is unclear whether hormone use during the menopausal transition or early postmenopause affects Alzheimer risk. Observational studies imply a protective association consistent with the so-called critical window hypothesis, but these findings could be biased. Clinical practice implications are presented.