Treatment of rheumatoid arthritis with blackcurrant seed oil.
Treatment of rheumatoid arthritis with blackcurrant seed oil.
复制标题
用黑加仑籽油治疗类风湿性关节炎。
DOI：
10.1093/rheumatology/33.9.847
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Zurier,RB
中科院分区：
文献类型：
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作者：
Leventhal,LJ;Boyce,EG;Zurier,RB
本研究的目的是评估黑加仑籽油（BCSO）的临床疗效和副作用，在RA和活动性滑膜炎患者中进行随机、双盲、安慰剂对照、24周试验。BCSO富含γ-亚麻酸（GLA）和亚麻油酸（ALA）。在动物模型中，GLA和源自ALA的二十碳五烯酸都能抑制炎症和关节组织损伤。BCSO治疗后RA患者的疾病活动性体征和症状明显减轻（P<0.05）。相比之下，服用安慰剂的患者疾病没有变化。治疗组的总体临床反应（四项指标的显著变化）并不比安慰剂组好。无患者因不良反应而退出BCSO治疗。然而，许多患者退出，因为BCSO及其安慰剂必须每天服用15粒大胶囊。尽管如此，该研究表明BCSO是活动性RA的潜在有效治疗方法。然而，必须找到方法来减少服用胶囊的大小和数量，以便在RA患者中进行更长时间的大型研究。
The objective of this study was to assess the clinical efficacy and side effects of blackcurrant seed oil (BCSO), in a randomized, double-blind, placebo controlled, 24-week trial in patients with RA and active synovitis. BCSO is rich in gammalinolenic acid (GLA) and alphalinoleinc acid (ALA). Both GLA and eicosapentaenoic acid which derives from ALA suppress inflammation and joint tissue injury in animal models. Treatment with BCSO resulted in reduction in signs and symptoms of disease activity in patients with RA (P<0.05). In contrast, patients given a placebo showed no change in disease. Overall clinical responses (significant change in four measures) were no better in the treatment group than in the placebo group. No patients withdrew from BCSO treatment because of adverse reactions. However, many patients withdrew because BCSO and its placebo had to be administered in 15 large capsules daily. Nonetheless, the study indicates that BCSO is a potentially effective treatment for active RA. However, means must be found to reduce the size and number of capsules taken, so that larger studies of longer duration in RA patients can be done.