Design and evaluation of novel polyanhydride blends as nerve guidance conduits
Design and evaluation of novel polyanhydride blends as nerve guidance conduits
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DOI：
10.1016/j.actbio.2009.11.023
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发表时间：
2010-06-01
影响因子：
9.7
通讯作者：
Uhrich, Kathryn E.
中科院分区：
文献类型：
--
作者：
Griffin, Jeremy;Carbone, Ashley;Uhrich, Kathryn E.
植入式可生物降解神经引导导管（NGC）具有排列和支持再生细胞以及防止疤痕形成的潜力。在这项研究中，使用由新型聚酸酐混合物制成的神经引导导管材料进行了体外生物测定和体内材料评估。对成纤维细胞和原代鸡神经元的体外细胞毒性研究表明，所提出的聚酐混合物无细胞毒性。在大鼠皮下植入 7 天，产生初始纤维蛋白基质、最少的巨噬细胞存在以及周围组织中的血管生成。由所提出的聚酸酐共混材料制成的神经导管可以作为有利的生物相容性组织工程装置。 (C) 2009 Acta Materialia Inc. 由 Elsevier Ltd 出版。保留所有权利。
Implantable biodegradable nerve guidance conduits (NGCs) have the potential to align and support regenerating cells, as well as prevent scar formation. In this study in vitro bioassays and in vivo material evaluations were performed using a nerve guidance conduit material made from a novel polyanhydride blend. In vitro cytotoxicity studies with both fibroblasts and primary chick neurons demonstrated that the proposed polyanhydride blend was non-cytotoxic. Subcutaneous implantation for 7 days in rats resulted in an initial fibrin matrix, minimal macrophage presence and angiogenesis in the surrounding tissues. Nerve guidance conduits fabricated from the proposed polyanhydride blend material may serve as favorable biocompatible tissue engineering devices. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.