A homodinuclear cobalt complex for the catalytic asymmetric Michael reaction of β-ketoesters to nitroolefins
A homodinuclear cobalt complex for the catalytic asymmetric Michael reaction of β-ketoesters to nitroolefins
复制标题
β-酮酯催化不对称迈克尔反应生成硝基烯烃的同双核钴配合物
DOI：
10.1039/c8ob00773j
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发表时间：
2018-05-28
影响因子：
3.2
通讯作者：
Zhou, Hui
中科院分区：
文献类型：
--
作者：
Chen, Guanghui;Liang, Guojuan;Zhou, Hui
合成了一种同双核Co-2/氨基苯酚磺酰胺配合物，用于α-酮酯与硝基烯烃的不对称Michael反应。该方法能够耐受广泛的底物，并且还可以获得优异的结果（高达99%的产率，>99：1 dr和98%ee）。此外，该反应可以在50 mmol规模下进行，而不会降低对映选择性和反应性。在机理研究的基础上，我们提出了Co-2/2a络合物可能是催化剂的活性物种，并描述了一个可能的催化循环。
A homodinuclear Co-2/aminophenol sulfonamide complex has been developed for the asymmetric Michael reaction of -ketoesters with nitroolefins. This procedure is capable of tolerating a wide range of substrates and excellent results (up to 99% yield, >99:1 dr and 98% ee) can also be obtained. Moreover, the reaction could be carried out on a 50 mmol scale without any decrease in the enantioselectivity and reactivity. On the basis of the results of mechanistic studies, we proposed that the Co-2/2a complex would be the active species and a possible catalytic cycle was described.