Feasibility of simultaneous intracranial EEG-fMRI in humans: A safety study
Feasibility of simultaneous intracranial EEG-fMRI in humans: A safety study
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DOI：
10.1016/j.neuroimage.2009.07.062
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Lemieux, Louis
中科院分区：
文献类型：
--
作者：
Carmichael, David W.;Thornton, John S.;Lemieux, Louis
在癫痫患者的大脑中植入电极作为其术前评估的一部分，同时颅内EEG和功能磁共振成像（icEEG-fMRI）可以提供重要的定位信息，并提高对潜在神经病理学的理解。本文从理论上分析了icEEG-fMRI对患者健康的潜在危害，认为其主要风险为：瞬时磁效应对电极产生的机械力、与脉冲射频场相互作用引起的组织加热以及与切换梯度磁场相互作用引起的组织刺激。这些潜在的危险在体外实验中使用Brain Products MR兼容EEG系统在Siemens 3 T Trio、1.5 T Avanto和GE 3 T Signa Excite扫描仪上进行了检查，未观察到电极弯曲。温度测量结果表明，可能会发生远高于指导限值的加热。然而，加热可以保持在安全范围内（
In epilepsy patients who have electrodes implanted in their brains as part of their pre-surgical assessment, simultaneous intracranial EEG and fMRI (icEEG-fMRI) may provide important localising information and improve understanding of the underlying neuropathology. However, patient safety during icEEG-fMRI has not been addressed.Here the potential health hazards associated with icEEG-fMRI were evaluated theoretically and the main risks identified as: mechanical forces on electrodes from transient magnetic effects, tissue heating due to interaction with the pulsed RF fields and tissue stimulation due to interactions with the switched magnetic gradient fields. These potential hazards were examined experimentally in vitro on a Siemens 3 T Trio, 1.5 T Avanto and a GE 3 T Signa Excite scanner using a Brain Products MR compatible EEG system.No electrode flexion was observed. Temperature measurements demonstrated that heating well above guideline limits can occur. However heating could be kept within safe limits (