Hydrogels for Therapeutic Delivery: Current Developments and Future Directions
Hydrogels for Therapeutic Delivery: Current Developments and Future Directions
复制标题
DOI：
10.1021/acs.biomac.6b01604
复制
发表时间：
2017-02-01
影响因子：
6.2
通讯作者：
Hennink, Wim E.
中科院分区：
文献类型：
--
作者：
Buwalda, Sytze J.;Vermonden, Tina;Hennink, Wim E.
水凝胶是用于控制释放治疗剂的有吸引力的材料，因为它们能够将生物活性剂包埋在它们的水溶胀网络中。有机和聚合物化学、生物工程和纳米技术的最新进展导致了用于治疗递送的水凝胶领域的若干新发展。在这个视角中，我们提出了我们对该领域最新技术的看法，从而专注于一些令人兴奋的主题，包括生物正交交联方法，多组分水凝胶，刺激响应性水凝胶，纳米凝胶以及从3D打印水凝胶中释放治疗剂。我们还描述了应该克服的挑战，以促进从学术界到临床的翻译，最后，我们分享我们对这个快速发展的研究领域的未来的想法。
Hydrogels are attractive materials for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. Recent advances in organic and polymer chemistry, bioengineering and nanotechnology have resulted in several new developments in the field of hydrogels for therapeutic delivery. In this Perspective, we present our view on the state-of-the-art in the field, thereby focusing on a number of exciting topics, including bioorthogonal cross-linking methods, multi component hydrogels, stimuli-responsive hydrogels, nanogels, and the release of therapeutics from 3D printed hydrogels. We also describe the challenges that should be overcome to facilitate translation from academia to the clinic and last, we share our ideas about the future of this rapidly evolving area of research.