MATHEMATICAL-MODEL OF HUMAN TEMPERATURE REGULATORY SYSTEM - TRANSIENT COLD-EXPOSURE RESPONSE
MATHEMATICAL-MODEL OF HUMAN TEMPERATURE REGULATORY SYSTEM - TRANSIENT COLD-EXPOSURE RESPONSE
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DOI：
10.1109/tbme.1976.324601
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发表时间：
1976-01-01
影响因子：
4.6
通讯作者：
HORVATH, SM
中科院分区：
文献类型：
--
作者：
GORDON, RG;ROEMER, RB;HORVATH, SM
提出了一种人体体温调节系统的数学模型，该模型利用有限差分技术，包含了新的解剖和基本生理信息，比以前的模型更详细。提出了一种冷应力控制系统，包括基于头部核心温度的反馈信号和基于皮肤温度和皮肤热流密度的前馈信号。对模型和直接实验结果(7个温度、心输出量、新陈代谢和手臂血流量)进行了比较。结果表明，皮肤热通量可能是温度调节系统的一个重要输入。
A mathematical model of the human temperature regulatory system which utilizes finite difference techniques and includes new anatomical and basal physiological information, with more detail than previous models, is presented. A cold stress control system which includes both a feedback signal based on head core temperature and feedforward signals based on the skin temperature and the skin heat flux is postulated. Model and direct experimental results (seven temperatures, cardiac output, metabolism, and arm blood flow) are compared for a transient cold exposure. The substantial agreement found suggests that the skin heat flux could be an important input to the temperature regulatory system.