Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline.
Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline.
复制标题
固定的染色质和二价结构域促进了男性种系的有丝分裂 - 渗透性转变。
DOI：
10.1186/s12915-015-0159-8
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发表时间：
2015-07-22
期刊：
影响因子：
5.4
通讯作者：
Namekawa SH
中科院分区：
文献类型：
--
作者：
Sin HS;Kartashov AV;Hasegawa K;Barski A;Namekawa SH
The male germline transcriptome changes dramatically during the mitosis-to-meiosis transition to activate late spermatogenesis genes and to transiently suppress genes commonly expressed in somatic lineages and spermatogenesis progenitor cells, termed somatic/progenitor genes. These changes reflect epigenetic regulation. Induction of late spermatogenesis genes during spermatogenesis is facilitated by poised chromatin established in the stem cell phases of spermatogonia, whereas silencing of somatic/progenitor genes during meiosis and postmeiosis is associated with formation of bivalent domains which also allows the recovery of the somatic/progenitor program after fertilization. Importantly, during spermatogenesis mechanisms of epigenetic regulation on sex chromosomes are different from autosomes: X-linked somatic/progenitor genes are suppressed by meiotic sex chromosome inactivation without deposition of H3K27me3. Our results suggest that bivalent H3K27me3 and H3K4me2/3 domains are not limited to developmental promoters (which maintain bivalent domains that are silent throughout the reproductive cycle), but also underlie reversible silencing of somatic/progenitor genes during the mitosis-to-meiosis transition in late spermatogenesis. The online version of this article (doi:10.1186/s12915-015-0159-8) contains supplementary material, which is available to authorized users.
