Directional cell movement during early development of the teleost Blennius pholis: II. Transformation of the cells of epithelial clusters into dendritic melanocytes, their dissociation from each other, and their migration to and invasion of the pectoral f
Directional cell movement during early development of the teleost Blennius pholis: II. Transformation of the cells of epithelial clusters into dendritic melanocytes, their dissociation from each other, and their migration to and invasion of the pectoral f
复制标题
硬骨鱼Blennius pholis早期发育过程中的定向细胞运动：II。
DOI：
10.1002/jez.1402480108
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Trinkaus,JP
中科院分区：
文献类型：
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作者：
Trinkaus,JP
在色素上皮细胞簇在黄的卵黄囊中静止不动2-4天后（Trinkaus，'88），它们的组成细胞转化为间充质树突状黑素细胞。然后这些黑素细胞彼此分离，并定向迁移到两侧发育中的胸鳍芽（PFB）。这些变化中的每一个都以近远侧序列发生，从最接近每个PFB的上皮簇开始。即使是单个的簇也符合这个顺序，近端首先解离。最终，所有黑素细胞到达并侵入PFB。这是100%有效的形态发生细胞运动。在这个发育过程完成时，每个PFB充满了黑素细胞，黑素细胞排列成弧形，其丝状伪足向外延伸，卵黄囊中没有色素细胞。这些细胞的形式和表面活性与它们的运动性和它们的运动速率被详细考虑。试图了解这些细胞迁移的方向性所涉及的力量进行说明。最后，简要讨论了这些观察结果对形态发生细胞运动以及上皮细胞和间充质细胞之间关系的意义。
After clusters of pigmented epithelial cells have rested immobile in the yolk sac ofBlennius pholisfor 2–4 days (Trinkaus, '88), their constituent cells transform into mesenchymal, dendritic melanocytes. Then these melanocytes dissociate from one another and migrate directionally toward the developing pectoral fin bud (PFB) on either side. Each of these changes takes place in a proximodistal sequence, starting with the epithelial cluster closest to each PFB. Even individual clusters conform to this sequence, the proximal side dissociating first. Eventually,allmelanocytes reach and invade the PFB. This is a 100% efficient morphogenetic cell movement. At the completion of this developmental sequence, each PFB is filled with melanocytes arranged in an arc with their filopodia extending outward and the yolk sac is bereft of pigment cells. The form and surface activity of these cells in relation to their motility and to their rate of movement are considered in detail. Attempts to understand the forces involved in giving directionality to these cell migrations are described. Finally, the significance of these observations for morphogenetic cell movements generally and for the relation between epithelial and mesenchymal cells is discussed briefly.