Correction for the Presence of Intravascular Oxygen-15 in the Steady-State Technique for Measuring Regional Oxygen Extraction Ratio in the Brain: 1. Description of the Method
Correction for the Presence of Intravascular Oxygen-15 in the Steady-State Technique for Measuring Regional Oxygen Extraction Ratio in the Brain: 1. Description of the Method
复制标题
测量大脑局部氧提取率的稳态技术中血管内 Oxygen-15 存在的校正： 1. 方法说明
DOI：
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复制
发表时间：
1983
影响因子：
6.3
通讯作者：
T. Jones
中科院分区：
文献类型：
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作者：
A. Lammertsma;T. Jones
氧-15稳态吸入技术提供了局部脑血流量、氧提取分数和氧利用率的定量值。然而，这最后两个，已被发现高于使用动静脉差分技术的报告。在理论上，这种高估是由于来自未提取的血管内氧-15的信号。在本文中，提出了一种方法来纠正这种血管内成分利用局部脑血容量的测量。定义了由于这种校正而施加的统计惩罚。
The oxygen-15 steady-state inhalation technique provides quantitative values of regional cerebral blood flow, fractional oxygen extraction, and oxygen utilisation. These last two, however, have been found to be higher than those reported using arteriovenous difference techniques. On theoretical grounds, this overestimation is due to the signal from nonextracted intravascular oxygen-15. In this paper, a method is presented to correct for this intravascular component utilising a measurement of regional cerebral blood volume. The statistical penalty imposed as a result of this correction is defined.