Infection with Trichomonas vaginalis increases the risk of HIV-1 acquisition
Infection with Trichomonas vaginalis increases the risk of HIV-1 acquisition
复制标题
DOI：
10.1086/511278
复制
发表时间：
2007-03-01
影响因子：
6.4
通讯作者：
Baeten, Jared M.
中科院分区：
文献类型：
--
作者：
McClelland, R. Scott;Sangare, Laura;Baeten, Jared M.
我们在肯尼亚蒙巴萨的妇女中进行了一项前瞻性研究，以确定阴道毛滴虫感染是否与人类免疫缺陷病毒1型（HIV-1）感染风险增加有关。在每月的随访中，进行了HIV-1和生殖道感染的实验室筛查。在1335名HIV-1血清阴性的女性中，有806例阴道生殖道感染（23.6/100人年），265例血清转化为HIV-1（7.7/100人年）。在对潜在混杂因素进行校正后，滴虫病与HIV-1感染风险增加1.52倍（95%置信区间，1.04-2.24倍）相关。治疗和预防阴道生殖道感染可降低妇女感染HIV-1的风险。
We conducted a prospective study among women in Mombasa, Kenya, to determine whether Trichomonas vaginalis infection was associated with an increased risk of human immunodeficiency virus type 1 ( HIV-1) infection. At monthly follow-up visits, laboratory screening for HIV-1 and genital tract infections was conducted. Among 1335 HIV-1-seronegative women monitored for a median of 566 days, there were 806 incident T. vaginalis infections ( 23.6/100 person-years), and 265 women seroconverted to HIV-1 ( 7.7/100 person-years). Trichomoniasis was associated with a 1.52-fold ( 95% confidence interval, 1.04-2.24-fold) increased risk of HIV-1 acquisition after adjustment for potential confounding factors. Treatment and prevention of T. vaginalis infection could reduce HIV-1 risk in women.