Synthesis of D- and L-Carbocyclic Nucleosides via Rhodium-Catalyzed Asymmetric Hydroacylation as the Key Step
Synthesis of D- and L-Carbocyclic Nucleosides via Rhodium-Catalyzed Asymmetric Hydroacylation as the Key Step
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DOI：
10.1021/ol801791g
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发表时间：
2008-11-06
期刊：
影响因子：
5.2
通讯作者：
Castillon, Sergio
中科院分区：
文献类型：
--
作者：
Marce, Patricia;Diaz, Yolanda;Castillon, Sergio
以铑/杜洛埃催化的对映选择性氢酰化反应为关键步骤，通过一种新的合成方法合成了D-和L-碳环核苷。通过酮的立体选择性还原和动态动力学拆分（DKR）得到3-羟甲基环戊醇中间体。
D- and L-carbocyclic nucleosides were obtained by a new procedure involving an enantioselective rhodium/duphos-catalyzed hydroacylation reaction as the key step. The 3-hydroxymethyl-cyclopentanol intermediate was obtained by stereoselective reduction of ketone and by dynamic kinetic resolution (DKR).