Clinical and histologic evaluation of human intrabony defects treated with an enamel matrix protein derivative (Emdogain).
Clinical and histologic evaluation of human intrabony defects treated with an enamel matrix protein derivative (Emdogain).
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发表时间：
2000-08
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通讯作者：
A. Sculean;G. Chiantella;P. Windisch;N. Donos
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作者：
A. Sculean;G. Chiantella;P. Windisch;N. Donos
釉基质蛋白衍生物（Emdogain）最近已被证明可以促进实验性凹陷型缺损的牙周再生。然而，关于Emdogain治疗后骨内牙周缺损的愈合，只有有限的人体组织学数据可用。因此，本研究的目的是介绍在骨内缺损中应用Emdogain后的临床和组织学结果。2例边缘性牙周炎和邻近牙齿的深部骨内缺损患者接受Emdogain治疗。两例病例的术后愈合期均顺利。治疗后6个月，两个标本中均发现新形成的牙骨质和插入的胶原纤维。在1例病例中，新附件形成还伴有骨新生。这项人体组织学研究的结果表明，Emdogain具有刺激人骨内缺损中新结缔组织附着形成的潜力。
An enamel matrix protein derivative (Emdogain) has been recently shown to promote periodontal regeneration in experimentally created recession-type defects. However, only limited histologic data from human material are available concerning the healing of intrabony periodontal defects following treatment with Emdogain. The aim of the present study was therefore to present the clinical and histologic results following the application of Emdogain in intrabony defects. Two patients with marginal periodontitis and deep intrabony defects adjacent to teeth scheduled for extraction were treated with Emdogain. The postoperative healing phase was uneventful in both cases. At 6 months following treatment, newly formed cementum with inserting collagen fibers was found in both specimens. In one case, the new attachment formation was also accompanied by bone neoformation. The results of this human histologic study indicate that Emdogain possesses the potential to stimulate new connective tissue attachment formation in human intrabony defects.