Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians.
Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians.
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DOI：
10.1210/jcem.86.11.7992
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发表时间：
2001-11
期刊：
影响因子：
--
通讯作者：
Annaswamy Raji;E. Seely;R. Arky;D. Simonson
中科院分区：
文献类型：
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作者：
Annaswamy Raji;E. Seely;R. Arky;D. Simonson
先前的研究表明，与白人相比，亚洲印度人（AIs）具有胰岛素抵抗性，患糖尿病和冠心病的风险较高。为了研究体脂分布的差异是否会导致这种风险，12名年龄和体重指数（BMI）匹配的健康AI和12名白人进行了75 g口服葡萄糖耐量试验，2小时正常血糖高胰岛素钳夹，腹部（L2-3）计算机断层扫描，空腹血脂和纤溶酶原激活物抑制剂-1（派-1）水平。尽管空腹血糖水平相似，但AI显示空腹高胰岛素血症（P = 0.001），血糖升高（P = 0.03）和胰岛素（P = 0.004）水平，并且在钳夹期间降低葡萄糖处置速率（R（d））（4.7 +/- 0.4对7.5 +/- 0.3 mg/kg/min，P < 0.0001）。AI组高密度脂蛋白水平显著降低，低密度脂蛋白水平显著升高，派-1水平显著升高（P = 0.01）。尽管BMI相似，但AI的总腹部脂肪（P = 0.04）和内脏脂肪（P = 0.04）显著更高。在所有受试者中，脂肪量测量值与钳夹期间的R（d）呈负相关（r = -0.47至-0.61，P < 0.01-0.001）。内脏脂肪量与甘油三酯、低密度脂蛋白和高密度脂蛋白相关（P < 0.002-0.0001）。派-1与R（d）呈负相关（r =-0.70，P < 0.01），而在白种人中则无相关性（r =-0.24，P = 0.44）。与白种人相比，对于相似的BMI和年龄，健康的AI具有胰岛素抵抗、血脂异常和心血管风险增加的生理标志物。身体脂肪分布的改变，特别是内脏脂肪的增加，可能会导致这些异常。
Previous studies have shown that Asian Indians (AIs) are insulin resistant and at high risk for developing diabetes and coronary heart disease, compared with Caucasians. To examine whether differences in body fat distribution contribute to this risk, 12 healthy AIs and 12 Caucasians matched for age and body mass index (BMI) underwent a 75-g oral glucose tolerance test, 2-h euglycemic hyperinsulinemic clamp, abdominal (L2-3) computed tomography scan, and fasting lipid and plasminogen activator inhibitor-1 (PAI-1) levels. Despite similar fasting plasma glucose levels, AIs exhibited fasting hyperinsulinemia (P = 0.001), higher glucose (P = 0.03) and insulin (P = 0.004) levels during the oral glucose tolerance test, and reduced glucose disposal rate (R(d)) (4.7 +/- 0.4 vs. 7.5 +/- 0.3 mg/kg per min, P < 0.0001) during the clamp. AIs had significantly lower high-density lipoprotein, higher low-density lipoprotein, and significantly higher PAI-1 levels (P = 0.01). Despite similar BMI, AIs had significantly greater total abdominal fat (P = 0.04) and visceral fat (P = 0.04). In all subjects, measures of fat mass were inversely correlated with R(d) during the clamp (r = -0.47 to -0.61, P < 0.01-0.001). Visceral fat mass was correlated with triglycerides, low-density lipoprotein, and high-density lipoprotein (P < 0.002-0.0001). PAI-1 was inversely correlated with R(d) in AIs (r = -0.70, P < 0.01) and not in Caucasians (r = -0.24, P = 0.44). For comparable BMI and age, healthy AIs have physiologic markers for insulin resistance, dyslipidemia, and increased cardiovascular risk, compared with Caucasians. Alterations in body fat distribution--particularly increased visceral fat--may contribute to these abnormalities.