Purinergic mechanism in the immune system: A signal of danger for dendritic cells.
Purinergic mechanism in the immune system: A signal of danger for dendritic cells.
复制标题
免疫系统中的嘌呤能机制：树突状细胞的危险信号。
DOI：
10.1007/s11302-005-6312-z
复制
发表时间：
2005-09
影响因子：
3.5
通讯作者：
Di Virgilio, Francesco
中科院分区：
文献类型：
--
作者：
Di Virgilio, Francesco
越来越多的人认识到，受损或应激的细胞释放具有调节树突细胞成熟能力的分子。这些分子的作用被认为是警告身体即将发生的危险，并启动和塑造随后的免疫反应。核苷酸非常适合于这一任务，因为它们在细胞膜损伤时容易释放，在细胞外环境中快速扩散，并连接树突细胞和其他单核吞噬细胞表达的特异性质膜受体。更好地了解细胞外核苷酸对树突状细胞应答的调节可能会提供新的途径来增强免疫应答并增加疫苗接种的功效。
There is increasing appreciation that injured or stressed cells release molecules endowed with the ability to modulate dendritic cell maturation. The role of these molecules is thought to be that of alerting the body of an impending danger, and initiate and shape the subsequent immune response. Nucleotides are perfectly suited for this task as they are easily released upon damage of the cell membrane, rapidly diffuse in the extracellular environment and ligate specific plasma membrane receptors expressed by dendritic cells and other mononuclear phagocytes. A better knowledge of the modulation of dendritic cell responses by extracellular nucleotides may provide novel routes to enhance the immune response and increase the efficacy of vaccination.