Strong association between c-myb and oestrogen-receptor expression in human breast cancer.
Strong association between c-myb and oestrogen-receptor expression in human breast cancer.
复制标题
DOI：
--
复制
发表时间：
1990
期刊：
影响因子：
8
通讯作者：
M. Guérin;Sheng Zm;N. Andrieu;G. Riou
中科院分区：
文献类型：
--
作者：
M. Guérin;Sheng Zm;N. Andrieu;G. Riou
以前的文章报道，c-myb原癌基因在造血系统的各种类型的肿瘤中被激活，这表明该基因在这些恶性肿瘤的发展中起作用。然而，尚未在实体原发性肿瘤中进行c-myb基因的研究。在本研究中，我们分析了乳腺癌中的c-myb基因，目的是确定其参与肿瘤进展。从169个癌标本中分析了c-myb癌基因的表达，这些癌标本来自未经治疗的非炎性乳腺癌（NBC）（112例患者）和炎性乳腺癌（IBC）（57例患者）。在108例（64%）肿瘤中检测到3.5kb的c-myb转录带。发现c-myb表达与良好的预后因素相关（P = 0.01）、雌孕激素受体状态（P <10（-4））和pS2基因表达（P <10（-4））与预后较差的乳腺癌IBC（P = 0.03）和多淋巴结转移的NBC（P = 0.15）呈负相关。其他基因（c-myc，c-erbB 2，c-fos和表皮生长因子受体）也进行了研究。c-myb基因表达与c-erbB 2过表达呈负相关（P <0.03）。当使用逐步过程的逻辑回归模型分析数据时，发现c-myb表达仅与雌激素受体状态相关（P <10（-4））。总之，我们的数据表明，分析c-myb在乳腺癌中的表达可以使一类新的雌激素依赖性肿瘤的特征。
Previous articles have reported that the c-myb proto-oncogene was activated in various types of tumours of the hematopoietic system suggesting that this gene plays a role in the development of these malignancies. However no studies of the c-myb gene have as yet been performed in solid primary tumours. In the present study we have analysed in breast cancer the c-myb gene with the aim to determine its involvement in tumour progression. Expression of the c-myb oncogene was analysed from 169 carcinoma specimens obtained from untreated patients with non-inflammatory breast cancer (NBC) (112 patients) and inflammatory breast cancer (IBC) (57 patients). A 3.5 kb c-myb transcript band was detected in 108 (64%) tumours. c-myb expression was found to be associated with good prognostic factors (lowest histopathologic grade (P = 0.01), oestrogen and progesterone receptor status (P less than 10(-4)) and pS2 gene expression (P less than 10(-4)) and negatively correlated with breast cancers of poorer prognosis, namely IBC (P = 0.03) and NBC with multiple involved nodes (P = 0.15). Other genes (c-myc, c-erbB2, c-fos and epidermal growth factor receptor) were also studied. The c-myb gene expression was found to be inversely correlated (P less than 0.03) with only c-erbB2 overexpression in NBC. When data were analysed with a logistic regression model using a stepwise procedure, c-myb expression was found to be associated only with the oestrogen receptor status (P less than 10(-4)). In conclusion, our data indicate that analysis of c-myb expression in breast cancer could allow the characterization of a new class of oestrogen-dependent tumours.