Genetic heterogeneity in breast cancer: the road to personalized medicine?
Genetic heterogeneity in breast cancer: the road to personalized medicine?
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DOI：
10.1186/1741-7015-11-151
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发表时间：
2013-06-18
期刊：
影响因子：
9.3
通讯作者：
Caldas C
中科院分区：
文献类型：
--
作者：
Baird RD;Caldas C
当今世界，死于乳腺癌的女性比死于任何其他类型的恶性肿瘤的女性还要多。乳腺癌的临床病程因患者而异。虽然其中一些变异性可以通过传统的临床病理因素（包括患者年龄、肿瘤分期、组织学分级和雌激素受体状态）来解释，但分子谱研究已经定义了具有不同临床结果的乳腺癌亚型。这篇小型评论考虑了最近使用基因组学技术的研究，试图确定预后和治疗反应的新生物标志物。这些研究强调了乳腺癌在空间和时间上存在的遗传异质性。
More women die from breast cancer across the world today than from any other type of malignancy. The clinical course of breast cancer varies tremendously between patients. While some of this variability is explained by traditional clinico-pathological factors (including patient age, tumor stage, histological grade and estrogen receptor status), molecular profiling studies have defined breast cancer subtypes with distinct clinical outcomes. This mini-review considers recent studies which have used genomics technologies in an attempt to identify new biomarkers of prognosis and treatment response. These studies highlight the genetic heterogeneity that exists within breast cancers in space and time.
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DOI：
10.1073/pnas.0912708107
发表时间：
2010-04-13
影响因子：
11.1
作者：
Gatza, Michael L.;Lucas, Joseph E.;Nevins, Joseph R.
通讯作者：
Nevins, Joseph R.
影响因子：
64.8
作者：
Curtis, Christina;Shah, Sohrab P.;Chin, Suet-Feung;Turashvili, Gulisa;Rueda, Oscar M.;Dunning, Mark J.;Speed, Doug;Lynch, Andy G.;Samarajiwa, Shamith;Yuan, Yinyin;Graef, Stefan;Ha, Gavin;Haffari, Gholamreza;Bashashati, Ali;Russell, Roslin;McKinney, Steven;Langerod, Anita;Green, Andrew;Provenzano, Elena;Wishart, Gordon;Pinder, Sarah;Watson, Peter;Markowetz, Florian;Murphy, Leigh;Ellis, Ian;Purushotham, Arnie;Borresen-Dale, Anne-Lise;Brenton, James D.;Tavare, Simon;Caldas, Carlos;Aparicio, Samuel
通讯作者：
Aparicio, Samuel