Packed-Bed Microreactor for Continuous-Flow Adipic Acid Synthesis from Cyclohexene and Hydrogen Peroxide
Packed-Bed Microreactor for Continuous-Flow Adipic Acid Synthesis from Cyclohexene and Hydrogen Peroxide
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DOI：
10.1002/ceat.201200703
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发表时间：
2013-06
影响因子：
2.1
通讯作者：
M. Shang;T. Noël;Q. Wang;V. Hessel
中科院分区：
文献类型：
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作者：
M. Shang;T. Noël;Q. Wang;V. Hessel
在连续流动填充床微反装置中，采用过氧化氢直接氧化环己烯合成己二酸。该反应以Na2WO4·2H2O为催化剂，以[CH3(n-C8H17)3N]HSO4为相转移催化剂，不加溶剂。对玻璃微珠尺寸、停留时间、过氧化氢浓度、酸的加入量、反应温度、反应物与催化剂的摩尔比等工艺参数进行了优化。结果表明，玻璃微珠越小，己二酸的产率越高，加酸在环己烯氧化制己二酸反应中起重要作用。基于新工艺窗口的概念，研究了温度升高的影响。
The synthesis of adipic acid by means of a direct oxidation of cyclohexene by hydrogen peroxide was carried out in a continuous-flow packed-bed microreactor. The reaction uses Na2WO4·2H2O as a catalyst and [CH3(n-C8H17)3N]HSO4 as a phase transfer catalyst without additional solvent. A parametric process optimization, such as glass beads size, residence time, concentration of hydrogen peroxide, addition of acid, reaction temperature, and molar ratios of reactants and catalysts, was performed. It is demonstrated that smaller glass beads result in a better yield of adipic acid and that the addition of acid plays an important role in the oxidation of cyclohexene to adipic acid. Based on the concept of Novel Process Windows, the influence of elevated temperatures is investigated.