Alterations in calcium transport and binding by the plasma membrane of mesenteric arteries from spontaneously hypertensive rats.
Alterations in calcium transport and binding by the plasma membrane of mesenteric arteries from spontaneously hypertensive rats.
复制标题
自发性高血压大鼠肠系膜动脉质膜钙转运和结合的改变。
DOI：
10.1159/000158114
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
E. Daniel
中科院分区：
文献类型：
--
作者：
J. W. Wei;R. Janis;E. Daniel
研究了Sr ~（++）、Ba ~（++）和Mn ~（++）对自发性高血压大鼠（SHR）肠系膜动脉质膜富集组分钙摄取的影响，以确定二价阳离子相互作用的改变与高血压的关系。在ATP存在下，SHR的这一组分的~（45）Ca ~（++）摄取量显著高于正常血压大鼠（NWR）。Ba++、Sr++和非放射性Ca++可降低这两种大鼠的45 Ca ++摄取，但Mn++不能降低;这些阳离子与45 Ca ++竞争的能力顺序为Ca++大于Sr++大于Ba++。与此相反，45 Ca ++摄取在ATP的情况下，由这个亚细胞级分从SHR是显着低于NWR的，这种被动的45 Ca ++结合可以取代Mn++除了其他阳离子。在阳离子对动脉质膜钙吸收的影响的研究中，发现SHR和NWR之间存在定性和定量的差异。这些结果表明，SHR的动脉质膜具有不同于NWR的钙结合和转运特性。然而，有没有一个完整的相关性之间的报告的阳离子对收缩的其他动脉在高血压和对钙的摄取SHR和NWR的膜。
The effect of Sr++, Ba++ and Mn++ on calcium uptake by a plasma membrane-enriched fraction from mesenteric arteries of spontaneously hypertensive rats (SHR) was studied to determine what alterations in divalent cation interactions are associated with hypertension. 45Ca++ uptake in the presence of ATP by this fraction from SHR was significantly greater than that of normotensive rats (NWR). This 45Ca++ uptake by these fractions from both types of rat could be reduced by Ba++, Sr++ and nonradioactive Ca++, but not by Mn++; the ability of these cations to compete with 45Ca++ was in the following order Ca++ greater than Sr++ greater than Ba++. In contrast, 45Ca++ uptake in the absence of ATP by this subcellular fraction from SHR was significantly less than that of NWR, and this passive 45Ca++ binding could be displaced by Mn++ in addition to the other cations. Both qualitative and quantitative differences were found between SHR and NWR in this study of the effects of cations on calcium uptake by arterial plasma membrane. These results suggest that the plasma membrane of SHR arteries has calcium-binding and transport properties that are different from those of NWR. However, there is not a complete correlation between the reported effects of the cations on contraction of other arteries in hypertension and on calcium uptake by membranes of SHR and NWR.