Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study.
Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study.
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DOI：
10.1016/j.ajog.2009.05.032
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发表时间：
2009-11
影响因子：
9.8
通讯作者：
Novack L
中科院分区：
文献类型：
--
作者：
Wiznitzer A;Mayer A;Novack V;Sheiner E;Gilutz H;Malhotra A;Novack L
该研究评估了妊娠期血脂谱的变化，无论是否伴有先兆子痫和/或妊娠期糖尿病。对9911名无心血管合并症的妇女在怀孕前一年和怀孕后一年之间的血脂谱进行了评估。妊娠期间的血脂水平变化很大，在受孕后达到最低点，在分娩时达到高峰。与孕前水平相比，总胆固醇水平从164.4 mg/dL增加到238.6 mg/dL，甘油三酯（TG）从92.6 mg/dL增加到238.4 mg/dL。复合终点（妊娠期糖尿病或先兆子痫）发生在1209名妇女（12.2%）。其患病率随TG-水平的升高而升高，从低TG组（经妊娠月份校正后，第25百分位数）的7.2%升高至高TG组（第75百分位数）的19.8%，但与高密度脂蛋白水平无关。在多变量分析中，较高的TG水平与主要终点相关，而低的高密度脂蛋白水平与主要终点无关。妊娠期间脂质水平变化很大。TG水平异常与妊娠并发症有关。
The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes. Lipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities. Lipid levels during gestation varied substantially with a nadir following conception and a peak at delivery. Compared to preconception levels total cholesterol levels increased from 164.4 mg/dL to 238.6 mg/dL and triglycerides (TGs) from 92.6 mg/dL to 238.4 mg/dL. The composite endpoint (gestational diabetes mellitus or preeclampsia) occurred in 1209 women (12.2%). Its prevalence increased with levels of TG—from 7.2% in the group with low TGs (<25th percentile adjusted for the gestational month) to 19.8% in the group with high TGs (>75th percentile), but was not associated with high-density lipoprotein levels. In multivariate analysis higher TGs levels, but not low high-density lipoprotein, were associated with the primary endpoint. Lipid levels change substantially during gestation. Abnormal levels of TGs are associated with pregnancy complications.