Low levels of N-acetyl aspartate in the left dorsolateral prefrontal cortex of pediatric bipolar patients.
Low levels of N-acetyl aspartate in the left dorsolateral prefrontal cortex of pediatric bipolar patients.
复制标题
儿科双相情感障碍患者左背外侧前额皮质中 N-乙酰天冬氨酸水平较低。
DOI：
10.1089/cap.2007.0102
复制
发表时间：
2007
影响因子：
1.9
通讯作者：
Soares,JairC
中科院分区：
文献类型：
--
作者：
Olvera,ReneL;Caetano,SheilaC;Fonseca,Manoela;Nicoletti,Mark;Stanley,JeffreyA;Chen,HuaHsuan;Hatch,JohnP;Hunter,Kristina;Pliszka,StevenR;Soares,JairC
背景：越来越多的证据表明，儿童双相情感障碍（BP）患者的额叶皮质结构、功能和神经化学异常。我们对儿童BP患者的左背外侧前额叶皮层（DLPFC）进行了单体素质子磁共振波谱（1H MRS），期望该脑区内的n -乙酰-天冬氨酸（NAA）水平低于健康对照受试者。方法：研究35例小儿血压（ⅰ型血压23例，ⅱ型血压12例，平均年龄±SD = 13.2±2.9岁，女性18例）和36例健康对照（平均年龄±SD = 13.7±2.6岁，女性17例）。短回波时间，单体素1h光谱接近点分辨光谱（PRESS）序列，代谢物的测量在1.5T飞利浦MR系统上进行。结果：与健康对照组相比，BP组左侧DLPFC的NAA水平显著降低（F= 4.21, df = 1,68,p= 0.04）。磷酸肌酸+肌酸（PCr+Cr）、甘油磷酸胆碱+磷酸胆碱（GPC+PC）、肌醇（mI）和谷氨酸在各组间无显著差异。进一步的分析显示，与对照组相比，青春期早期组的NAA显著降低（Mann-Whitney u检验统计量= 52.00,p= 0.014），但与其他青春期组相比，BP没有显著降低。结论：与健康受试者相比，BP受试者左侧DLPFC的NAA水平较低，提示该区域存在神经元功能障碍。
Background:Increasing evidence suggests abnormalities in the structure, function, and neurochemistry of the frontal cortex in pediatric bipolar (BP) patients. We conducted a single-voxel proton magnetic resonance spectroscopy (1H MRS) of the left dorsolateral prefrontal cortex (DLPFC) of pediatric BP patients, expecting lowerN-acetyl-aspartate (NAA) levels within that brain region compared to healthy comparison subjects.Methods:We studied 35 pediatric BP (23 BP type I, 12 BP type II; mean age ± SD = 13.2 ± 2.9 years; 18 females) and 36 healthy controls (mean age ± SD = 13.7 ± 2.6 years, 17 females). A short echo time, single-voxel1H spectroscopy approach point-resolved spectroscopy (PRESS) sequence, measurements of metabolites was performed on a 1.5T Philips MR system.Results:BP subjects had significantly lower NAA levels in the left DLPFC compared to healthy controls (F= 4.21, df = 1, 68,p= 0.04). There was not a significant difference between groups for phosphocreatine + creatine (PCr+Cr), glycerolphosphocholine + phosphocholine (GPC+PC), myo-inositol (mI), or glutamate. Further analyses revealed a significant reduction of NAA in our early puberty group compared to controls (Mann–Whitney U-test statistic = 52.00,p= 0.014), but not for BP versus controls in other pubertal groups.Conclusions: BP subjects have lower NAA levels in the left DLPFC compared to healthy subjects, suggesting neuronal dysfunction in this region.