Sleep deprivation-induced reduction in cortical functional response to serial subtraction
Sleep deprivation-induced reduction in cortical functional response to serial subtraction
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DOI：
10.1097/00001756-199912160-00004
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发表时间：
1999-12-16
期刊：
影响因子：
1.7
通讯作者：
Gillin, JC
中科院分区：
文献类型：
--
作者：
Drummond, SPA;Brown, GG;Gillin, JC
13名正常志愿者在正常睡眠和睡眠剥夺（SD）后的算术操作中进行了fMRI研究。目的包括确定前额叶皮层（PFC）和顶叶算术区是否容易受到SD的影响。在一个正常的夜晚睡眠后，激活定位于双侧PFC，顶叶和运动前区。SD后，这些区域的活动明显下降，尤其是PFC。从串行减法任务的数据是一致的家庭的PFC脆弱性假设，但根据这一点和其他研究，我们建议的本地化，功能的SD在大脑中的影响可能会有所不同，在一定程度上，与特定的认知任务。(C)1999年利平科特威廉姆斯&威尔金斯。
THIRTEEN normal volunteers were studied with fMRI during arithmetic performance after a normal night of sleep and following sleep deprivation (SD). Aims included determining whether the prefrontal cortex (PFC) and the parietal lobe arithmetic areas are vulnerable to the effects of SD. After a normal night of sleep, activation localized to the bilateral PFC, parietal lobes and premotor areas. Following SD, activity in these regions decreased markedly, especially in the PFC. Performance also dropped. Data from the serial subtraction task are consistent with Home's PFC vulnerability hypothesis but, based on this and other studies, we suggest the localized, functional effects of SD in the brain may vary, in part, with the specific cognitive task. (C) 1999 Lippincott Williams & Wilkins.