ADP-induced platelet aggregation in acute ischemic stroke patients on aspirin therapy
ADP-induced platelet aggregation in acute ischemic stroke patients on aspirin therapy
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DOI：
10.1111/j.1468-1331.2008.02306.x
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发表时间：
2008-12-01
影响因子：
5.1
通讯作者：
Kang, M. -J.
中科院分区：
文献类型：
--
作者：
Cha, J. -K.;Jeon, H. -W.;Kang, M. -J.
阿司匹林是预防急性缺血性卒中后再发缺血事件或死亡的重要治疗方案。为探讨阿司匹林治疗急性缺血性卒中患者二磷酸腺苷(ADP)诱导的血小板聚集程度与预后的关系，选择107例服用阿司匹林的急性缺血性卒中患者，在服药5天后用光学血小板聚集仪检测血小板功能，并观察其预后。生存分析采用Kaplan-Meyer曲线，对患者进行分层后，事件发生率分别为7.4%、9.3%和30.8%(P=0.023)。多因素Logistic回归分析显示，70岁以上高龄(OR13.7；95%CI2.14~88.07；P=0.001)和二磷酸腺苷诱导的血小板聚集率增高(OR1.1；95%CI1.01~1.20；P=0.026)与急性缺血性卒中后不良预后相关。
Aspirin is an important therapeutic regimen to prevent the recurrent ischemic events or death after acute ischemic stroke. In this study, we evaluated the relationship between the extent of adenosine diphosphate (ADP) -induced platelet aggregation and outcome in acute ischemic stroke patients on aspirin therapy.We selected 107 acute ischemic stroke patients who had been prescribed aspirin and evaluated platelet function test by using optic platelet aggregometer test after 5 days of taking it and investigated the prognosis 90 days after ischemic events. Kaplan-Meyer curve was used for survival analysis.After stratification of the subjected patients by tertiles of ADP-induced platelet aggregation, the events rates were 7.4%, 9.3% and 30.8% (P = 0.023). In multiple logistic regression analysis, old age over 70 years (OR, 13.7; 95% CI, 2.14-88.07; P = 0.001) and the increased ADP-induced platelet aggregation had independent significance to the risk of primary end-points after acute ischemic stroke (OR, 1.1; 95% CI 1.01 to 1.20; P = 0.026).This study showed that the increased ADP-induced platelet aggregation under using aspirin is associated with poor outcome after acute ischemic stroke.