Mechanisms pertaining to arsenic toxicity.
Mechanisms pertaining to arsenic toxicity.
复制标题
与砷毒性有关的机制。
DOI：
10.4103/0971-6580.84258
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发表时间：
2011-07
影响因子：
--
通讯作者：
Kaur T
中科院分区：
文献类型：
--
作者：
Singh AP;Goel RK;Kaur T
砷是一种环境污染物，其在饮用水中的污染被认为是对全球环境健康的严重威胁。慢性砷暴露是造成巨大健康困扰的一个原因，因为它会增加各种疾病的风险，例如心血管异常、糖尿病、神经毒性和肾毒性。此外，有人认为接触砷会影响肝功能并诱发肝毒性。此外，很少有研究证明长期接触砷会诱发致癌性，特别是皮肤癌、膀胱癌和肺癌。本综述探讨了砷引起的毒性和终末器官损伤发病机制中涉及的多种机制。
Arsenic is an environmental pollutant and its contamination in the drinking water is considered as a serious worldwide environmental health threat. The chronic arsenic exposure is a cause of immense health distress as it accounts for the increased risk of various disorders such as cardiovascular abnormalities, diabetes mellitus, neurotoxicity, and nephrotoxicity. In addition, the exposure to arsenic has been suggested to affect the liver function and to induce hepatotoxicity. Moreover, few studies demonstrated the induction of carcinogenicity especially cancer of the skin, bladder, and lungs after the chronic exposure to arsenic. The present review addresses diverse mechanisms involved in the pathogenesis of arsenic-induced toxicity and end-organ damage.