Antibodies against Ku protein in sera from patients with autoimmune diseases.
Antibodies against Ku protein in sera from patients with autoimmune diseases.
复制标题
自身免疫性疾病患者血清中抗 Ku 蛋白的抗体。
DOI：
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发表时间：
1989
影响因子：
4.6
通讯作者：
F. Arnett
中科院分区：
文献类型：
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作者：
M. Yaneva;F. Arnett
免疫亲和纯化的Ku蛋白用于筛选系统性红斑狼疮（SLE）、硬皮病、肌炎和Sjögren综合征患者的血清中抗Ku抗体的定量免疫印迹检测。159份被研究的血清中有16%与Ku蛋白有反应；在SLE（19%）和硬皮病（14%）血清中发现抗ku抗体的频率显著增加。肌炎和Sjögren综合征患者的发病频率相似。所有阳性血清均有Ku蛋白86kd亚基抗体；只有一种血清与70kd亚基无反应。比较抗ku阳性和阴性患者其他自身抗体的频率。只有抗sm抗体，特别是在没有抗nrnp的情况下，似乎与抗ku抗体的存在相关。抗ku抗体与II类HLA抗原DQw1（89%的阳性血清）之间存在很强的相关性，表明MHC基因参与了抗ku免疫反应的建立。
Immunoaffinity-purified Ku protein was used to screen sera from patients with systemic lupus erythematosus (SLE), scleroderma, myositis and Sjögren's syndrome for anti-Ku antibodies in a quantitative immunoblot assay. Sixteen percent of the 159 studied sera were reactive with the Ku protein; significantly increased frequencies of anti-Ku antibodies were found in SLE (19%) and scleroderma (14%) sera. Patients with myositis and Sjögren's syndrome showed similar frequencies. All positive sera had antibodies to the 86 kD subunit of Ku protein; only one serum did not react with 70 kD subunit. Frequencies of other autoantibodies were compared in anti-Ku positive and negative patients. Only anti-Sm antibodies, especially in the absence of anti-nRNP, appear to be associated with the presence of anti-Ku antibodies. A strong correlation between anti-Ku antibodies and the class II HLA antigen DQw1 (89% of the positive sera) was observed, suggesting participation of MHC genes in the mounting of the anti-Ku immune response.
类风湿性关节炎患病率高的齐珀瓦印第安亚群的 HLA-DR 特征。
影响因子：
2.7
作者：
Bias,WB;Hsu,SH;Pollard,MK;Harvey,J;Lotze,MT;Arnett,FC;Stevens,MB
通讯作者：
Stevens,MB