Hierarchy of prediction errors for auditory events in human temporal and frontal cortex
Hierarchy of prediction errors for auditory events in human temporal and frontal cortex
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DOI：
10.1073/pnas.1525030113
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发表时间：
2016-06-14
影响因子：
11.1
通讯作者：
Knight, Robert T.
中科院分区：
文献类型：
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作者：
Duerschmid, Stefan;Edwards, Erik;Knight, Robert T.
预测编码理论假设，神经网络学习环境中的统计规则，以便与实际结果进行比较，当感觉偏差发生时，发出预测错误(PE)的信号。听觉中的PE研究利用了低频事件相关电位(LF-ERPs)，如失配性负波。然而，局部皮质活动被高频段[高频伽马段(H)：80-150赫兹]很好地标示出来。我们使用额叶和颞叶的硬膜下电极的皮层脑电记录，比较了人类H和LF-ERP在异常检测中的模式。患者在两种情况下听与任务无关的音调，这两种情况在重复背景刺激(完全可预测的和不可预测的偏差)的可预测性上不同。我们发现在外侧颞叶和额叶下部皮质的两个频段都有与异常相关的反应，H的潜伏期比LF-ERPs的潜伏期更早。关键的是，额叶H活动而不是LF-ERP区分完全可预测的变化和不可预测的变化，额叶皮质对不可预测的事件敏感。这些结果突出了额叶皮质和H.活动在异常检测和PE产生中的作用。
Predictive coding theories posit that neural networks learn statistical regularities in the environment for comparison with actual outcomes, signaling a prediction error (PE) when sensory deviation occurs. PE studies in audition have capitalized on low-frequency event-related potentials (LF-ERPs), such as the mismatch negativity. However, local cortical activity is well-indexed by higher-frequency bands [high-gamma band (H.): 80-150 Hz]. We compared patterns of human H. and LF-ERPs in deviance detection using electrocorticographic recordings from subdural electrodes over frontal and temporal cortices. Patients listened to trains of task-irrelevant tones in two conditions differing in the predictability of a deviation from repetitive background stimuli (fully predictable vs. unpredictable deviants). We found deviance-related responses in both frequency bands over lateral temporal and inferior frontal cortex, with an earlier latency for H. than for LF-ERPs. Critically, frontal H. activity but not LF-ERPs discriminated between fully predictable and unpredictable changes, with frontal cortex sensitive to unpredictable events. The results highlight the role of frontal cortex and H. activity in deviance detection and PE generation.