SPECIFICITY OF THE EFFECT OF REPEATED HANDLING ON SYMPATHETIC-ADRENOMEDULLARY AND PITUITARY-ADRENOCORTICAL ACTIVITY IN RATS
SPECIFICITY OF THE EFFECT OF REPEATED HANDLING ON SYMPATHETIC-ADRENOMEDULLARY AND PITUITARY-ADRENOCORTICAL ACTIVITY IN RATS
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DOI：
10.1016/0306-4530(93)90001-2
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发表时间：
1993-01-01
影响因子：
3.7
通讯作者：
JEZOVA, D
中科院分区：
文献类型：
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作者：
DOBRAKOVOVA, M;KVETNANSKY, R;JEZOVA, D
在大鼠中研究了垂体-肾上腺皮质和交感-肾上腺髓质系统对单次和重复处理的反应。重复处理（14天，每天3 x 1 min或1天，每隔30 min 6 x 1 min）后，观察到血浆肾上腺素和ACTH水平降低，而去甲肾上腺素水平升高至与首次处理后相同的程度。当重复处理的大鼠由不同的人处理时，激素反应发生了改变：ACTH和肾上腺素反应的减少不再明显，而去甲肾上腺素反应增强。在短时间内（3小时）重复处理的情况下，由不同人员进行的最后一次处理不会改变降低的激素反应。对重复操作的行为习惯化是血浆ACTH和肾上腺素水平的适应。观察到的血浆肾上腺素和去甲肾上腺素反应的分离表明，不同的途径控制肾上腺髓质和外周交感神经系统的反应。
The response of the pituitary-adrenocortical and sympathetic-adrenomedullary system to single and repeated handling was studied in rats. After repeated handling (14 days, 3 x 1 min daily or 1 day, 6 x 1 min at 30 min intervals) a reduction of plasma epinephrine and ACTH level was observed, while norepinephrine levels increased to the same extent as after the first handling. When repeatedly handled rats were handled by a different person, hormonal responses were altered: The reduction in the ACTH and epinephrine response was no longer apparent, whereas the norepinephrine response was potentiated. In the case of repeated handling over a short time period (3 hr) the last handling by a different person did not alter the reduced hormonal response. Behavioral habituation to repeated handling paralleled adaptation of plasma ACTH and epinephrine levels. The observed dissociation of plasma epinephrine and norepinephrine response suggests that different pathways control the response of the adrenal medulla and the peripheral sympathetic nervous system.