TREM2: A new player in the tumor microenvironment.
TREM2: A new player in the tumor microenvironment.
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DOI：
10.1016/j.smim.2023.101739
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发表时间：
2023-03
影响因子：
7.8
通讯作者：
Martina Molgora;Yizhou A Liu;M. Colonna;M. Cella
中科院分区：
文献类型：
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作者：
Martina Molgora;Yizhou A Liu;M. Colonna;M. Cella
TREM2是一种骨髓细胞受体，已在神经炎症和神经退行性疾病的背景下广泛描述。最近，TREM2成为肿瘤中巨噬细胞功能的重要调节因子。TREM2缺陷或阻断在不同的鼠模型中提供保护并促进对抗PD1的应答。在人类肿瘤中，表达TREM2的巨噬细胞存在于许多群组和肿瘤类型中，并且通常与免疫抑制和不良预后相关。在这里，我们提供了TREM2在肿瘤中的影响的概述，考虑到目前的文献，重点是小鼠模型和人类癌症。
TREM2 is a myeloid cell receptor that has been extensively described in the context of neuroinflammation and neurodegenerative diseases. Recently, TREM2 emerged as a crucial regulator of macrophage function in tumors. TREM2-deficiency or blockade provide protection and promote the response to anti-PD1 in different murine models. In human tumors, TREM2-expressing macrophages are present in numerous cohorts and tumor types and are generally associated with immunosuppression and poor prognosis. Here, we provide an overview of the impact of TREM2 in tumors considering current literature, with a focus on both murine models and human cancer.