Effect of adenosine on transmural myocardial blood flow distribution in the awake dog.
Effect of adenosine on transmural myocardial blood flow distribution in the awake dog.
复制标题
腺苷对清醒狗透壁心肌血流分布的影响。
DOI：
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发表时间：
1980
影响因子：
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通讯作者：
J. Greenfield
中科院分区：
文献类型：
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作者：
J. Rembert;L. M. Boyd;W. Watkinson;J. Greenfield
研究确定了腺苷对跨壁心肌血流分布的影响。将最大剂量和次最大剂量的腺苷注入清醒的静息状态的狗，这些狗长期使用冠状动脉血流探头以及主动脉和左房压力导管。用放射性微球(8~10微米)测定局部冠脉血流量。评价了四种实验方案：1)最大剂量(1.00 mg.Kg-1。Min-1)以及次最大(0.45 mg.Kg-1。Min-1)腺苷的血管扩张水平，2)腺苷的剂量-反应特性，3)潘生丁的剂量-反应特性，以及4)腺苷在动脉血氧分压升高时的作用。结果表明，最大剂量的腺苷扩张血管对心内膜-心外膜血流比率影响不大，而次最大剂量的腺苷对心内膜血流灌注有明显的优势。这种心内膜灌注量的相对增加不会因高氧而改变。在次最大剂量下，双嘧达莫向心内膜层产生类似的优先流。这些数据表明，血管扩张剂对腺苷输注的反应性在心内膜层更大，
Studies were conducted to determine the effects of adenosine on transmural myocardial blood flow distribution. Both maximal and submaximal vasodilatory doses of adenosine were infused into awake resting dogs chronically instrumented with coronary flow probes and aortic and left atrial pressure catheters. Radioactive microspheres (8-10 micron) were used to determine regional coronary blood flow. Four experimental protocols were evaluated: 1) the effects of maximal (1.00 mg . kg-1 . min-1) as well as submaximal (0.45 mg . kg-1 . min-1) vasodilatory levels of adenosine, 2) the dose-response characteristics of adenosine, 3) the dose-response characteristics of dipyridamole, and 4) the effects of adenosine in the presence of an increased arterial PO2. The data indicate that maximal vasodilatory doses of adenosine have little effect on the endocardial-to-epicardial blood flow ratio, whereas submaximal doses result in a marked preferential endocardial perfusion. This relative increase in endocardial perfusion was not altered by hyperoxia. Dipyridamole, in submaximal doses, produced a similar preferential flow to the endocardial layer. These data demonstrate that the vasodilator reactivity to adenosine infusion is greater in the endocardial layer,