COMPARED WITH DIETARY MONOUNSATURATED AND SATURATED FAT, POLYUNSATURATED FAT PROTECTS AFRICAN-GREEN MONKEYS FROM CORONARY-ARTERY ATHEROSCLEROSIS
COMPARED WITH DIETARY MONOUNSATURATED AND SATURATED FAT, POLYUNSATURATED FAT PROTECTS AFRICAN-GREEN MONKEYS FROM CORONARY-ARTERY ATHEROSCLEROSIS
复制标题
DOI：
10.1161/01.atv.15.12.2101
复制
发表时间：
1995-12-01
影响因子：
8.7
通讯作者：
SAWYER, JK
中科院分区：
文献类型：
--
作者：
RUDEL, LL;PARKS, JS;SAWYER, JK
将富含饱和、n-6多不饱和和单硫代脂肪酸的致动脉粥样硬化饮食喂给非洲绿色猴5年，以确定对血浆脂蛋白和冠状动脉粥样硬化的影响。喂食多不饱和脂肪和单不饱和脂肪的猴子的血浆LDL胆固醇浓度相似，这些值显着低于喂食饱和脂肪的动物的LDL。血浆HDL胆固醇浓度在喂食饱和和单不饱和脂肪的动物中相当，并且显著高于喂食多不饱和脂肪的动物。因此，单不饱和脂肪组的LDL/HDL比率最低。饱和脂肪组和单不饱和脂肪组的LDL颗粒尺寸最大，显着大于多不饱和脂肪组。LDL颗粒富集胆固醇油酸酯是最大的动物喂养的单不饱和脂肪，其次是饱和脂肪喂养的动物，是最少的多不饱和脂肪喂养的动物。冠状动脉粥样硬化内膜面积测量是少的多不饱和脂肪与饱和脂肪组相比，是少的动物喂养的多不饱和脂肪与单不饱和脂肪喂养的动物相比，但没有单不饱和和饱和脂肪组之间的差异。胆固醇酯，特别是胆固醇油酸酯，在冠状动脉中的积累也是相似的单不饱和脂肪和饱和脂肪组之间，但在动物喂食多不饱和脂肪是最小的。总之，喂食单不饱和脂肪的猴子与喂食饱和脂肪的猴子发生了等量的冠状动脉粥样硬化，但喂食多不饱和脂肪的猴子发生的较少。喂食单不饱和脂肪的动物中低LDL和高HDL的有益作用显然被LDL颗粒成分中致动脉粥样硬化的变化所抵消。饮食中的多不饱和脂肪似乎导致冠状动脉粥样硬化最少，因为它可以防止胆固醇油酸酯在这些灵长类动物的LDL和冠状动脉中积累。
Atherogenic diets enriched in saturated, n-6 polyunsaturated, and monounsafurated fatty acids were fed to African green monkeys for 5 years to define effects on plasma lipoproteins and coronary artery atherosclerosis. The monkeys fed polyunsaturated and monounsaturated fat had similar plasma concentrations of LDL cholesterol, and these values were significantly lower than for LDL in the animals fed saturated fat. Plasma HDL cholesterol concentrations were comparable in animals fed saturated and monounsaturated fat and were significantly higher than in animals fed polyunsaturated fat. Thus, the monounsaturated fat group had the lowest LDL/HDL ratio. LDL particle size was largest in the saturated and monounsaturated fat groups, significantly larger than in the polyunsaturated fat group. LDL particle enrichment with cholesteryl oleate was the greatest in the animals fed monounsaturated fat, next greatest in the saturated fat-fed animals, and was least in the polyunsaturated fat-fed animals. Coronary artery atherosclerosis as measured by intimal area was less in the polyunsaturated fat compared with the saturated fat groups, was less in the animals fed polyunsaturated fat compared with the monounsaturated fat-fed animals, but did not differ between the monounsaturated and saturated fat groups. Cholesteryl ester, particularly cholesteryl oleate, accumulation in the coronary arteries was also similar between groups fed monounsaturated and saturated fat but was minimal in the animals fed polyunsaturated fat. In sum, the monkeys fed monounsaturated fat developed equivalent amounts of coronary artery atherosclerosis as those fed saturated fat, but monkeys fed polyunsaturated fat developed less. The beneficial effects of the lower LDL and higher HDL in the animals fed monounsaturated fat apparently were offset by the atherogenic shifts in LDL particle composition. Dietary polyunsaturated fat appears to result in the least amount of coronary artery atherosclerosis because it prevents cholesteryl oleate accumulation in LDL and the coronary arteries in these primates.