Heart genetics in a small package, exploiting the condensed genome of Ciona intestinalis
Heart genetics in a small package, exploiting the condensed genome of Ciona intestinalis
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DOI：
10.1093/bfgp/elt034
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发表时间：
2014-01-01
影响因子：
4
通讯作者：
Davidson, Brad
中科院分区：
文献类型：
--
作者：
Cota, Christina D.;Segade, Fernando;Davidson, Brad
心源性细胞命运的初始建立中的缺陷可能导致普遍的人类先天性心脏异常。然而，新生心脏命运诱导的分子基础已被证明难以破译。在这篇综述中，我们探讨了参与细胞外，细胞和核因子的全面规范网络。在每一个层面上，我们详细阐述了通过研究无脊椎脊索动物玻璃海鞘心脏发生的见解，并提出了未来研究的生产线。深入讨论心前诱导的目的是作为一个范例，说明潜在的使用玻璃海鞘来阐明全面的网络基础上的其他方面的脊索心脏发生，包括定向迁移和subspecification的心脏和咽谱系。
Defects in the initial establishment of cardiogenic cell fate are likely to contribute to pervasive human congenital cardiac abnormalities. However, the molecular underpinnings of nascent cardiac fate induction have proven difficult to decipher. In this review we explore the participation of extracellular, cellular and nuclear factors in comprehensive specification networks. At each level, we elaborate on insights gained through the study of cardiogenesis in the invertebrate chordate Ciona intestinalis and propose productive lines of future research. In-depth discussion of pre-cardiac induction is intended to serve as a paradigm, illustrating the potential use of Ciona to elucidate comprehensive networks underlying additional aspects of chordate cardiogenesis, including directed migration and subspecification of cardiac and pharyngeal lineages.