Linear relationship between cytoplasm resistance and hemoglobin in red blood cell hemolysis by electrical impedance spectroscopy & eight-parameter equivalent circuit
Linear relationship between cytoplasm resistance and hemoglobin in red blood cell hemolysis by electrical impedance spectroscopy & eight-parameter equivalent circuit
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电阻抗光谱法研究红细胞溶血中细胞质电阻与血红蛋白的线性关系
DOI：
10.1016/j.bios.2018.08.012
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发表时间：
2018
影响因子：
12.6
通讯作者：
Takei Masahiro
中科院分区：
文献类型：
--
作者：
Tran A. Kiet;Sapkota Achyut;Wen Jianming;Li Jianping;Takei Masahiro
我们已经开发了一种非侵入性的快速和实时的红细胞（RBC）溶血检测方法，这是一个更准确的护理点在各种医疗环境中的溶血测试。采用八参数等效电路来定量血红蛋白（Hb）和细胞质从RBC释放到血浆中。通过向血液中加入不同体积分数的蒸馏水来诱导RBC溶血。根据实验值估计RBC溶血后释放的细胞质。RBC溶血和血液电特性变化之间的密切关系已被证明。细胞质电阻（Rc）与Hb呈线性关系。R与Hb的关系式为Rc = 0.2203Hb+ 2.4775，相关系数为0.9905。
We have developed a non-invasive rapid and real-time red blood cell (RBC) hemolysis detection method which is a more accurate for point of care testing of hemolysis in various medical settings. An eight-parameter equivalent circuit is employed to quantify the release of hemoglobin (Hb) and the cytoplasm from RBC into the blood plasma. RBC hemolysis is induced by adding different volume fractions of distilled water into the blood. The cytoplasm released following RBC hemolysis is estimated from the experimental values. A strong relationship between RBC hemolysis and change in the electrical characteristics of blood has been demonstrated. The cytoplasm resistance (Rc) shows a linear relationship with theHb. This relationship betweenRcandHbis described by the equationRc= 0.2203Hb+ 2.4775, with a correlation coefficient of 0.9905.