Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities.
Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities.
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DOI：
10.1371/journal.pone.0256749
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Gharagouzloo C
中科院分区：
文献类型：
--
作者：
Leaston J;Ferris CF;Kulkarni P;Chandramohan D;van de Ven AL;Qiao J;Timms L;Sepulcre J;El Fakhri G;Ma C;Normandin MD;Gharagouzloo C
脑血管异常与阿尔茨海默病和相关痴呆症（ADRD）有关。已知ApoE-14（APOE 4）在神经血管功能障碍中起关键作用，然而当前的医学成像技术在定量方面受到限制。这项横断面研究测试了最近建立的成像模式，定量超短时间回波对比增强磁共振成像（QUTE-CE MRI）的可行性，以识别人类APOE 4基因敲入雌性大鼠（TGRA 8960）动物模型早期发育中的小血管异常。在8个月时，发现48.3%的脑体积具有显著的信号增加（75/173个解剖学分割区域;多重比较q<0.05）。值得注意的是，在三突触回路、小脑和杏仁核中检测到血管异常，所有这些都已知在整个AD病理学中功能下降，并且在学习和记忆中具有影响。用QUTE-CE MRI定量检测到的异常可能是过度血管化的结果，但也可能部分或全部是由于血脑屏障渗漏的贡献。进一步的探索与组织学验证是必要的，以验证病理原因。无论如何，这些结果表明，QUTE-CE MRI可以用APOE 4高灵敏度地检测神经血管功能障碍，并可能有助于为健康和疾病提供新的见解。
Cerebrovascular abnormality is linked to Alzheimer’s disease and related dementias (ADRDs). ApoE-Ɛ4 (APOE4) is known to play a critical role in neurovascular dysfunction, however current medical imaging technologies are limited in quantification. This cross-sectional study tested the feasibility of a recently established imaging modality, quantitative ultra-short time-to-echo contrast-enhanced magnetic resonance imaging (QUTE-CE MRI), to identify small vessel abnormality early in development of human APOE4 knock-in female rat (TGRA8960) animal model. At 8 months, 48.3% of the brain volume was found to have significant signal increase (75/173 anatomically segmented regions; q<0.05 for multiple comparisons). Notably, vascular abnormality was detected in the tri-synaptic circuit, cerebellum, and amygdala, all of which are known to functionally decline throughout AD pathology and have implications in learning and memory. The detected abnormality quantified with QUTE-CE MRI is likely a result of hyper-vascularization, but may also be partly, or wholly, due to contributions from blood-brain-barrier leakage. Further exploration with histological validation is warranted to verify the pathological cause. Regardless, these results indicate that QUTE-CE MRI can detect neurovascular dysfunction with high sensitivity with APOE4 and may be helpful to provide new insights into health and disease.
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影响因子：
4.8
作者：
Chen, Sining;Wang, Chi;Eberly, Lynn E.;Caffo, Brian S.;Schwartz, Brian S.
通讯作者：
Schwartz, Brian S.
影响因子：
16.6
作者：
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3.3
作者：
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影响因子：
1.2
作者：
Gharagouzloo, Codi A.;Timms, Liam;Sridhar, Srinivas
通讯作者：
Sridhar, Srinivas